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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IWS1
All Species:
17.58
Human Site:
S449
Identified Species:
29.74
UniProt:
Q96ST2
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96ST2
NP_060439.2
819
91955
S449
E
E
A
G
K
E
L
S
D
K
K
N
E
E
K
Chimpanzee
Pan troglodytes
XP_001139705
1089
121835
S719
E
E
A
G
K
E
L
S
D
K
K
N
E
E
K
Rhesus Macaque
Macaca mulatta
XP_001087787
827
93220
S449
E
E
A
G
K
E
L
S
D
K
K
N
E
E
K
Dog
Lupus familis
XP_533312
832
93567
S462
E
V
G
K
E
E
L
S
D
K
K
N
E
E
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8C1D8
766
85230
D429
D
I
F
G
E
S
G
D
E
E
E
E
E
F
T
Rat
Rattus norvegicus
Q3SWT4
764
85429
S426
I
A
D
I
F
G
E
S
G
D
E
E
E
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510535
927
102715
S556
V
E
D
G
K
E
E
S
G
K
K
N
E
E
K
Chicken
Gallus gallus
XP_422571
689
77823
D352
D
I
F
G
E
S
G
D
E
E
E
E
E
F
T
Frog
Xenopus laevis
Q6DE96
836
92684
K466
R
K
S
K
T
E
T
K
S
A
D
K
L
F
G
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097000
820
90557
G452
K
G
S
R
S
R
S
G
S
A
A
S
Q
T
A
Honey Bee
Apis mellifera
XP_624549
770
87091
I433
T
K
K
T
K
H
E
I
T
D
S
E
N
E
V
Nematode Worm
Caenorhab. elegans
Q19375
511
57235
D174
D
E
F
V
E
G
R
D
E
E
E
S
Q
E
T
Sea Urchin
Strong. purpuratus
XP_798740
798
90991
L444
K
K
K
S
S
N
V
L
S
S
D
D
D
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q06505
410
46064
N73
A
A
I
D
E
N
S
N
V
E
A
A
E
R
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.7
94.3
93.8
N.A.
84.7
82.4
N.A.
69.6
65
60.4
N.A.
N.A.
26.5
30.1
22.7
31.5
Protein Similarity:
100
74.8
96.1
95.3
N.A.
88.4
87.1
N.A.
75.8
73.7
72.9
N.A.
N.A.
46.7
48.8
37.3
50.9
P-Site Identity:
100
100
100
73.3
N.A.
13.3
20
N.A.
73.3
13.3
6.6
N.A.
N.A.
0
13.3
13.3
0
P-Site Similarity:
100
100
100
80
N.A.
46.6
33.3
N.A.
73.3
46.6
20
N.A.
N.A.
26.6
20
60
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
15
22
0
0
0
0
0
0
15
15
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
22
0
15
8
0
0
0
22
29
15
15
8
8
8
8
% D
% Glu:
29
36
0
0
36
43
22
0
22
29
29
29
65
58
8
% E
% Phe:
0
0
22
0
8
0
0
0
0
0
0
0
0
22
0
% F
% Gly:
0
8
8
43
0
15
15
8
15
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
15
8
8
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
15
22
15
15
36
0
0
8
0
36
36
8
0
0
43
% K
% Leu:
0
0
0
0
0
0
29
8
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
15
0
8
0
0
0
36
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% Q
% Arg:
8
0
0
8
0
8
8
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
15
8
15
15
15
43
22
8
8
15
0
0
0
% S
% Thr:
8
0
0
8
8
0
8
0
8
0
0
0
0
8
22
% T
% Val:
8
8
0
8
0
0
8
0
8
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _