Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IWS1 All Species: 22.73
Human Site: S621 Identified Species: 38.46
UniProt: Q96ST2 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96ST2 NP_060439.2 819 91955 S621 S A I K E W L S P L P D R S L
Chimpanzee Pan troglodytes XP_001139705 1089 121835 S891 S A I K E W L S P L P D R S L
Rhesus Macaque Macaca mulatta XP_001087787 827 93220 S621 S A I K E W L S P L P D R S L
Dog Lupus familis XP_533312 832 93567 S634 S A I K E W L S P L P D R S L
Cat Felis silvestris
Mouse Mus musculus Q8C1D8 766 85230 K586 K I R E E L L K I L Q E L P S
Rat Rattus norvegicus Q3SWT4 764 85429 L583 A L K I R E E L L K I L Q E L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510535 927 102715 S729 S A I K E W L S P L P D R S L
Chicken Gallus gallus XP_422571 689 77823 L509 L K I R E E L L K I L Q E L P
Frog Xenopus laevis Q6DE96 836 92684 T638 S A I K E W L T P L P D R S L
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097000 820 90557 A622 N V L T D W L A P L P N K S L
Honey Bee Apis mellifera XP_624549 770 87091 L590 S L K I R D S L L K L L W E F
Nematode Worm Caenorhab. elegans Q19375 511 57235 R331 P R F W K L D R S T L K Q S G
Sea Urchin Strong. purpuratus XP_798740 798 90991 K601 R P M A E W L K P L P D K S L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q06505 410 46064 D230 I W L E P L P D G S L P S F E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 74.7 94.3 93.8 N.A. 84.7 82.4 N.A. 69.6 65 60.4 N.A. N.A. 26.5 30.1 22.7 31.5
Protein Similarity: 100 74.8 96.1 95.3 N.A. 88.4 87.1 N.A. 75.8 73.7 72.9 N.A. N.A. 46.7 48.8 37.3 50.9
P-Site Identity: 100 100 100 100 N.A. 20 6.6 N.A. 100 20 93.3 N.A. N.A. 46.6 6.6 6.6 60
P-Site Similarity: 100 100 100 100 N.A. 33.3 20 N.A. 100 33.3 100 N.A. N.A. 86.6 6.6 20 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 32.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 43 0 8 0 0 0 8 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 8 8 8 0 0 0 50 0 0 0 % D
% Glu: 0 0 0 15 65 15 8 0 0 0 0 8 8 15 8 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 0 0 8 8 % F
% Gly: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 8 50 15 0 0 0 0 8 8 8 0 0 0 0 % I
% Lys: 8 8 15 43 8 0 0 15 8 15 0 8 15 0 0 % K
% Leu: 8 15 15 0 0 22 72 22 15 65 29 15 8 8 65 % L
% Met: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 8 8 0 0 8 0 8 0 58 0 58 8 0 8 8 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 8 8 15 0 0 % Q
% Arg: 8 8 8 8 15 0 0 8 0 0 0 0 43 0 0 % R
% Ser: 50 0 0 0 0 0 8 36 8 8 0 0 8 65 8 % S
% Thr: 0 0 0 8 0 0 0 8 0 8 0 0 0 0 0 % T
% Val: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 8 0 8 0 58 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _