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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IWS1 All Species: 24.85
Human Site: S720 Identified Species: 42.05
UniProt: Q96ST2 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96ST2 NP_060439.2 819 91955 S720 P Q R R R M N S T G G Q T P R
Chimpanzee Pan troglodytes XP_001139705 1089 121835 S990 P Q R R R M N S T G G Q T P R
Rhesus Macaque Macaca mulatta XP_001087787 827 93220 S728 P Q R R R M N S T G G Q T P R
Dog Lupus familis XP_533312 832 93567 S733 P Q R R R M N S T G G Q T P R
Cat Felis silvestris
Mouse Mus musculus Q8C1D8 766 85230 D676 G G Q T P R R D L E K V L T G
Rat Rattus norvegicus Q3SWT4 764 85429 R673 S T G G Q T P R R D L E K V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510535 927 102715 S828 P Q R R R M N S A G G Q T P R
Chicken Gallus gallus XP_422571 689 77823 R599 S G G Q T P R R D L E K V L T
Frog Xenopus laevis Q6DE96 836 92684 S737 P Q R R R M S S S G G Q T P R
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097000 820 90557 E724 R H K S P D T E P S S S S K A
Honey Bee Apis mellifera XP_624549 770 87091 K680 D D G S S S Q K S Q D I N K A
Nematode Worm Caenorhab. elegans Q19375 511 57235 I421 D Q P K R P R I R D A D E M G
Sea Urchin Strong. purpuratus XP_798740 798 90991 S701 A K R R R M S S D E T P E E K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q06505 410 46064 V320 E K L R K K S V M D S A K N R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 74.7 94.3 93.8 N.A. 84.7 82.4 N.A. 69.6 65 60.4 N.A. N.A. 26.5 30.1 22.7 31.5
Protein Similarity: 100 74.8 96.1 95.3 N.A. 88.4 87.1 N.A. 75.8 73.7 72.9 N.A. N.A. 46.7 48.8 37.3 50.9
P-Site Identity: 100 100 100 100 N.A. 0 0 N.A. 93.3 0 86.6 N.A. N.A. 0 0 13.3 33.3
P-Site Similarity: 100 100 100 100 N.A. 6.6 13.3 N.A. 93.3 13.3 100 N.A. N.A. 13.3 6.6 20 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 32.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 0 8 0 8 8 0 0 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 15 8 0 0 0 8 0 8 15 22 8 8 0 0 0 % D
% Glu: 8 0 0 0 0 0 0 8 0 15 8 8 15 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 15 22 8 0 0 0 0 0 43 43 0 0 0 15 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 8 0 0 0 8 0 0 0 % I
% Lys: 0 15 8 8 8 8 0 8 0 0 8 8 15 15 8 % K
% Leu: 0 0 8 0 0 0 0 0 8 8 8 0 8 8 8 % L
% Met: 0 0 0 0 0 50 0 0 8 0 0 0 0 8 0 % M
% Asn: 0 0 0 0 0 0 36 0 0 0 0 0 8 8 0 % N
% Pro: 43 0 8 0 15 15 8 0 8 0 0 8 0 43 0 % P
% Gln: 0 50 8 8 8 0 8 0 0 8 0 43 0 0 0 % Q
% Arg: 8 0 50 58 58 8 22 15 15 0 0 0 0 0 50 % R
% Ser: 15 0 0 15 8 8 22 50 15 8 15 8 8 0 0 % S
% Thr: 0 8 0 8 8 8 8 0 29 0 8 0 43 8 8 % T
% Val: 0 0 0 0 0 0 0 8 0 0 0 8 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _