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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CRBN
All Species:
29.09
Human Site:
S174
Identified Species:
53.33
UniProt:
Q96SW2
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96SW2
NP_057386.2
442
50546
S174
V
L
E
L
R
T
Q
S
D
G
I
Q
Q
A
K
Chimpanzee
Pan troglodytes
XP_001140181
383
43891
R131
A
Y
S
N
V
Q
E
R
E
A
Q
F
G
T
T
Rhesus Macaque
Macaca mulatta
XP_001100581
442
50550
S174
V
L
E
L
R
T
Q
S
D
G
I
Q
Q
A
K
Dog
Lupus familis
XP_533757
444
50959
S176
V
L
E
L
R
T
Q
S
D
G
I
Q
Q
A
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8C7D2
445
50862
S177
V
L
E
L
R
T
Q
S
D
G
I
Q
Q
A
K
Rat
Rattus norvegicus
Q56AP7
445
50859
S177
V
L
E
L
R
T
Q
S
D
G
I
Q
Q
A
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506395
672
76120
S161
V
L
E
I
R
T
Q
S
D
G
I
Q
Q
A
K
Chicken
Gallus gallus
P0CF65
445
51100
S175
V
L
E
I
R
T
Q
S
D
G
I
Q
Q
A
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q68EH9
431
49076
A165
V
H
D
I
R
T
Q
A
D
G
I
R
Q
A
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VH36
585
66434
S301
R
G
L
V
F
Y
K
S
R
A
L
Q
R
I
V
Honey Bee
Apis mellifera
XP_395264
404
46327
A148
D
Q
G
F
R
L
K
A
K
G
R
Q
R
F
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783498
893
103803
A170
V
M
E
T
R
R
Q
A
D
G
I
L
I
G
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001132097
564
63617
D216
E
V
Q
I
I
E
E
D
T
P
L
R
T
P
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.6
99.3
97
N.A.
95.2
95.2
N.A.
55.6
84.2
N.A.
69
N.A.
21
35.5
N.A.
22.6
Protein Similarity:
100
86.6
99.7
97.9
N.A.
97.7
97.7
N.A.
60.2
91.9
N.A.
82.8
N.A.
38.2
52.4
N.A.
33.7
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
93.3
93.3
N.A.
66.6
N.A.
13.3
26.6
N.A.
46.6
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
100
100
N.A.
93.3
N.A.
40
46.6
N.A.
66.6
Percent
Protein Identity:
N.A.
29.2
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
46.2
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
24
0
16
0
0
0
62
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
0
0
0
8
70
0
0
0
0
0
0
% D
% Glu:
8
0
62
0
0
8
16
0
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
8
8
0
0
0
0
0
0
8
0
8
0
% F
% Gly:
0
8
8
0
0
0
0
0
0
77
0
0
8
8
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
31
8
0
0
0
0
0
70
0
8
8
0
% I
% Lys:
0
0
0
0
0
0
16
0
8
0
0
0
0
0
70
% K
% Leu:
0
54
8
39
0
8
0
0
0
0
16
8
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% P
% Gln:
0
8
8
0
0
8
70
0
0
0
8
70
62
0
8
% Q
% Arg:
8
0
0
0
77
8
0
8
8
0
8
16
16
0
8
% R
% Ser:
0
0
8
0
0
0
0
62
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
8
0
62
0
0
8
0
0
0
8
8
8
% T
% Val:
70
8
0
8
8
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _