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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CRBN
All Species:
16.36
Human Site:
S214
Identified Species:
30
UniProt:
Q96SW2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96SW2
NP_057386.2
442
50546
S214
I
F
P
S
K
P
V
S
R
E
D
Q
C
S
Y
Chimpanzee
Pan troglodytes
XP_001140181
383
43891
L168
G
R
Q
R
F
K
V
L
E
L
R
T
Q
S
D
Rhesus Macaque
Macaca mulatta
XP_001100581
442
50550
S214
I
F
P
S
K
P
V
S
R
E
D
Q
C
S
Y
Dog
Lupus familis
XP_533757
444
50959
S216
I
F
P
S
K
P
V
S
W
E
D
Q
Y
S
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8C7D2
445
50862
S217
V
F
P
S
K
P
I
S
W
E
D
Q
Y
S
C
Rat
Rattus norvegicus
Q56AP7
445
50859
S217
I
F
P
S
K
P
I
S
W
E
D
Q
Y
S
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506395
672
76120
A201
L
F
P
S
K
P
I
A
W
E
D
Q
Y
A
L
Chicken
Gallus gallus
P0CF65
445
51100
V216
F
P
S
S
K
P
K
V
W
Q
D
R
A
F
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q68EH9
431
49076
T204
H
S
P
Q
T
K
H
T
Q
T
T
P
P
Q
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VH36
585
66434
Q346
Y
F
L
P
E
P
L
Q
T
V
D
M
G
S
M
Honey Bee
Apis mellifera
XP_395264
404
46327
E186
L
G
P
P
F
L
D
E
R
L
A
S
L
D
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783498
893
103803
P210
M
I
P
H
H
I
S
P
S
A
K
D
G
G
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001132097
564
63617
D297
D
S
M
K
S
S
S
D
E
D
G
D
L
M
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.6
99.3
97
N.A.
95.2
95.2
N.A.
55.6
84.2
N.A.
69
N.A.
21
35.5
N.A.
22.6
Protein Similarity:
100
86.6
99.7
97.9
N.A.
97.7
97.7
N.A.
60.2
91.9
N.A.
82.8
N.A.
38.2
52.4
N.A.
33.7
P-Site Identity:
100
13.3
100
80
N.A.
66.6
73.3
N.A.
53.3
26.6
N.A.
6.6
N.A.
26.6
13.3
N.A.
6.6
P-Site Similarity:
100
13.3
100
80
N.A.
80
80
N.A.
80
40
N.A.
20
N.A.
40
26.6
N.A.
13.3
Percent
Protein Identity:
N.A.
29.2
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
46.2
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
8
8
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
16
0
24
% C
% Asp:
8
0
0
0
0
0
8
8
0
8
62
16
0
8
8
% D
% Glu:
0
0
0
0
8
0
0
8
16
47
0
0
0
0
0
% E
% Phe:
8
54
0
0
16
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
8
8
0
0
0
0
0
0
0
0
8
0
16
8
0
% G
% His:
8
0
0
8
8
0
8
0
0
0
0
0
0
0
8
% H
% Ile:
31
8
0
0
0
8
24
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
54
16
8
0
0
0
8
0
0
0
8
% K
% Leu:
16
0
8
0
0
8
8
8
0
16
0
0
16
0
8
% L
% Met:
8
0
8
0
0
0
0
0
0
0
0
8
0
8
16
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
70
16
0
62
0
8
0
0
0
8
8
0
8
% P
% Gln:
0
0
8
8
0
0
0
8
8
8
0
47
8
8
0
% Q
% Arg:
0
8
0
8
0
0
0
0
24
0
8
8
0
0
8
% R
% Ser:
0
16
8
54
8
8
16
39
8
0
0
8
0
54
0
% S
% Thr:
0
0
0
0
8
0
0
8
8
8
8
8
0
0
0
% T
% Val:
8
0
0
0
0
0
31
8
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
39
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
31
0
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _