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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CRBN
All Species:
4.55
Human Site:
S25
Identified Species:
8.33
UniProt:
Q96SW2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.75
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96SW2
NP_057386.2
442
50546
S25
L
P
L
L
P
A
E
S
E
E
E
D
E
M
E
Chimpanzee
Pan troglodytes
XP_001140181
383
43891
Rhesus Macaque
Macaca mulatta
XP_001100581
442
50550
S25
L
P
L
L
P
A
E
S
E
E
E
D
E
M
E
Dog
Lupus familis
XP_533757
444
50959
E27
L
L
P
A
E
S
E
E
E
D
E
I
E
M
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8C7D2
445
50862
E28
L
P
A
D
S
E
D
E
D
D
E
I
E
M
E
Rat
Rattus norvegicus
Q56AP7
445
50859
E28
L
P
A
D
S
E
D
E
D
D
E
I
E
M
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506395
672
76120
E12
Q
A
W
E
S
E
D
E
E
D
E
N
E
M
E
Chicken
Gallus gallus
P0CF65
445
51100
E26
P
A
P
A
E
S
E
E
E
D
D
N
E
M
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q68EH9
431
49076
E13
Q
L
L
P
E
N
E
E
E
E
E
D
D
M
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VH36
585
66434
Q13
N
S
E
I
N
S
V
Q
A
R
D
E
D
V
Q
Honey Bee
Apis mellifera
XP_395264
404
46327
D8
M
D
A
N
V
D
D
D
G
T
H
S
E
L
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783498
893
103803
D25
P
D
D
D
A
D
E
D
S
V
E
E
D
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001132097
564
63617
D49
E
G
D
G
N
E
E
D
Y
D
V
D
A
F
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.6
99.3
97
N.A.
95.2
95.2
N.A.
55.6
84.2
N.A.
69
N.A.
21
35.5
N.A.
22.6
Protein Similarity:
100
86.6
99.7
97.9
N.A.
97.7
97.7
N.A.
60.2
91.9
N.A.
82.8
N.A.
38.2
52.4
N.A.
33.7
P-Site Identity:
100
0
100
46.6
N.A.
40
40
N.A.
33.3
33.3
N.A.
53.3
N.A.
0
13.3
N.A.
20
P-Site Similarity:
100
0
100
60
N.A.
60
60
N.A.
53.3
60
N.A.
60
N.A.
46.6
33.3
N.A.
33.3
Percent
Protein Identity:
N.A.
29.2
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
46.2
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
24
16
8
16
0
0
8
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
16
24
0
16
31
24
16
47
16
31
24
8
0
% D
% Glu:
8
0
8
8
24
31
54
47
47
24
62
16
62
0
77
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
8
0
8
0
0
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
24
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
39
16
24
16
0
0
0
0
0
0
0
0
0
8
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
62
0
% M
% Asn:
8
0
0
8
16
8
0
0
0
0
0
16
0
0
0
% N
% Pro:
16
31
16
8
16
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
16
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
0
8
0
0
24
24
0
16
8
0
0
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% T
% Val:
0
0
0
0
8
0
8
0
0
8
8
0
0
8
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _