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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CRBN
All Species:
31.82
Human Site:
T332
Identified Species:
58.33
UniProt:
Q96SW2
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96SW2
NP_057386.2
442
50546
T332
Q
C
Q
E
T
E
I
T
T
K
N
E
I
F
S
Chimpanzee
Pan troglodytes
XP_001140181
383
43891
P274
N
L
K
D
D
S
L
P
S
N
P
I
D
F
S
Rhesus Macaque
Macaca mulatta
XP_001100581
442
50550
T332
Q
C
Q
E
T
E
I
T
T
K
N
E
I
F
S
Dog
Lupus familis
XP_533757
444
50959
T334
Q
C
Q
E
T
E
I
T
T
K
N
E
I
F
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8C7D2
445
50862
T335
Q
C
Q
E
T
E
I
T
T
K
N
E
I
F
S
Rat
Rattus norvegicus
Q56AP7
445
50859
T335
Q
C
Q
E
T
E
I
T
T
K
N
E
I
F
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506395
672
76120
T319
Q
C
Q
D
T
E
I
T
T
K
N
E
I
F
S
Chicken
Gallus gallus
P0CF65
445
51100
T334
Q
C
Q
D
T
E
I
T
T
K
N
E
I
F
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q68EH9
431
49076
T322
Q
C
Q
D
T
E
I
T
S
K
N
E
I
F
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VH36
585
66434
C465
C
N
S
S
L
A
L
C
S
D
L
F
A
M
S
Honey Bee
Apis mellifera
XP_395264
404
46327
L293
L
Q
R
E
I
K
Y
L
V
E
D
K
I
F
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783498
893
103803
L458
T
R
R
D
F
D
M
L
V
N
H
A
R
Y
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001132097
564
63617
L448
L
Q
K
E
I
Q
L
L
K
A
F
N
H
I
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.6
99.3
97
N.A.
95.2
95.2
N.A.
55.6
84.2
N.A.
69
N.A.
21
35.5
N.A.
22.6
Protein Similarity:
100
86.6
99.7
97.9
N.A.
97.7
97.7
N.A.
60.2
91.9
N.A.
82.8
N.A.
38.2
52.4
N.A.
33.7
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
93.3
93.3
N.A.
86.6
N.A.
6.6
20
N.A.
6.6
P-Site Similarity:
100
40
100
100
N.A.
100
100
N.A.
100
100
N.A.
100
N.A.
20
53.3
N.A.
46.6
Percent
Protein Identity:
N.A.
29.2
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
46.2
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
0
8
0
8
8
0
0
% A
% Cys:
8
62
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
39
8
8
0
0
0
8
8
0
8
0
0
% D
% Glu:
0
0
0
54
0
62
0
0
0
8
0
62
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
8
8
0
77
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% H
% Ile:
0
0
0
0
16
0
62
0
0
0
0
8
70
8
0
% I
% Lys:
0
0
16
0
0
8
0
0
8
62
0
8
0
0
8
% K
% Leu:
16
8
0
0
8
0
24
24
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% M
% Asn:
8
8
0
0
0
0
0
0
0
16
62
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% P
% Gln:
62
16
62
0
0
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
16
0
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
0
8
8
0
8
0
0
24
0
0
0
0
0
85
% S
% Thr:
8
0
0
0
62
0
0
62
54
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _