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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CRBN
All Species:
35.76
Human Site:
Y245
Identified Species:
65.56
UniProt:
Q96SW2
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96SW2
NP_057386.2
442
50546
Y245
T
S
W
P
R
W
L
Y
S
L
Y
D
A
E
T
Chimpanzee
Pan troglodytes
XP_001140181
383
43891
L199
S
T
M
S
A
V
Q
L
E
S
L
N
K
C
Q
Rhesus Macaque
Macaca mulatta
XP_001100581
442
50550
Y245
T
S
W
P
R
W
L
Y
S
L
Y
D
A
E
T
Dog
Lupus familis
XP_533757
444
50959
Y247
T
S
W
P
R
W
L
Y
S
L
Y
D
A
E
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8C7D2
445
50862
Y248
T
S
W
P
R
W
L
Y
S
L
Y
D
A
E
T
Rat
Rattus norvegicus
Q56AP7
445
50859
Y248
T
S
W
P
R
W
L
Y
S
L
Y
D
A
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506395
672
76120
Y232
T
S
W
P
P
W
L
Y
S
L
Y
D
A
E
T
Chicken
Gallus gallus
P0CF65
445
51100
Y247
T
S
W
P
P
W
L
Y
S
L
Y
D
A
E
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q68EH9
431
49076
Y235
T
S
W
P
P
W
V
Y
S
L
Y
D
S
K
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VH36
585
66434
P377
Q
L
S
T
T
T
W
P
S
D
A
C
Q
E
Y
Honey Bee
Apis mellifera
XP_395264
404
46327
V217
V
E
N
L
D
A
I
V
T
P
W
P
A
W
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783498
893
103803
Y241
T
W
W
P
P
W
V
Y
E
M
Y
D
A
D
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001132097
564
63617
T328
S
S
H
S
D
K
K
T
N
M
R
N
D
N
N
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.6
99.3
97
N.A.
95.2
95.2
N.A.
55.6
84.2
N.A.
69
N.A.
21
35.5
N.A.
22.6
Protein Similarity:
100
86.6
99.7
97.9
N.A.
97.7
97.7
N.A.
60.2
91.9
N.A.
82.8
N.A.
38.2
52.4
N.A.
33.7
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
93.3
93.3
N.A.
73.3
N.A.
13.3
6.6
N.A.
53.3
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
93.3
93.3
N.A.
93.3
N.A.
13.3
26.6
N.A.
73.3
Percent
Protein Identity:
N.A.
29.2
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
46.2
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
0
0
0
8
0
70
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% C
% Asp:
0
0
0
0
16
0
0
0
0
8
0
70
8
8
0
% D
% Glu:
0
8
0
0
0
0
0
0
16
0
0
0
0
62
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
8
8
0
0
0
0
0
8
8
0
% K
% Leu:
0
8
0
8
0
0
54
8
0
62
8
0
0
0
0
% L
% Met:
0
0
8
0
0
0
0
0
0
16
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
8
0
0
16
0
8
8
% N
% Pro:
0
0
0
70
31
0
0
8
0
8
0
8
0
0
0
% P
% Gln:
8
0
0
0
0
0
8
0
0
0
0
0
8
0
8
% Q
% Arg:
0
0
0
0
39
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
16
70
8
16
0
0
0
0
70
8
0
0
8
0
0
% S
% Thr:
70
8
0
8
8
8
0
8
8
0
0
0
0
0
62
% T
% Val:
8
0
0
0
0
8
16
8
0
0
0
0
0
0
8
% V
% Trp:
0
8
70
0
0
70
8
0
0
0
8
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
70
0
0
70
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _