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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPEN All Species: 6.67
Human Site: S1073 Identified Species: 29.33
UniProt: Q96T58 Number Species: 5
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96T58 NP_055816.2 3664 402248 S1073 C Q E L A S I S V G S G S R P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q62504 3644 398736 S1088 C Q D P A A V S A G S G S R P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514992 1879 199498
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8SX83 5560 599981 S2404 A K L M M L S S A D S D D T D
Honey Bee Apis mellifera XP_395705 4346 474873 N1360 D S D N S G H N A L R E S K E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784255 4378 488332 T1448 A L E E R L R T V D A M M K Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. N.A. N.A. 81.1 N.A. N.A. 30 N.A. N.A. N.A. N.A. 22.1 22.8 N.A. 20.7
Protein Similarity: 100 N.A. N.A. N.A. N.A. 87 N.A. N.A. 37.8 N.A. N.A. N.A. N.A. 35.9 38.4 N.A. 37.9
P-Site Identity: 100 N.A. N.A. N.A. N.A. 66.6 N.A. N.A. 0 N.A. N.A. N.A. N.A. 13.3 6.6 N.A. 13.3
P-Site Similarity: 100 N.A. N.A. N.A. N.A. 86.6 N.A. N.A. 0 N.A. N.A. N.A. N.A. 26.6 33.3 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 34 0 0 0 34 17 0 0 50 0 17 0 0 0 0 % A
% Cys: 34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 17 0 34 0 0 0 0 0 0 34 0 17 17 0 17 % D
% Glu: 0 0 34 17 0 0 0 0 0 0 0 17 0 0 17 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 17 0 0 0 34 0 34 0 0 0 % G
% His: 0 0 0 0 0 0 17 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 17 0 0 0 0 0 0 0 0 % I
% Lys: 0 17 0 0 0 0 0 0 0 0 0 0 0 34 0 % K
% Leu: 0 17 17 17 0 34 0 0 0 17 0 0 0 0 0 % L
% Met: 0 0 0 17 17 0 0 0 0 0 0 17 17 0 0 % M
% Asn: 0 0 0 17 0 0 0 17 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 17 0 0 0 0 0 0 0 0 0 0 34 % P
% Gln: 0 34 0 0 0 0 0 0 0 0 0 0 0 0 17 % Q
% Arg: 0 0 0 0 17 0 17 0 0 0 17 0 0 34 0 % R
% Ser: 0 17 0 0 17 17 17 50 0 0 50 0 50 0 0 % S
% Thr: 0 0 0 0 0 0 0 17 0 0 0 0 0 17 0 % T
% Val: 0 0 0 0 0 0 17 0 34 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _