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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPEN All Species: 5.76
Human Site: S2918 Identified Species: 25.33
UniProt: Q96T58 Number Species: 5
    Phosphosite Substitution
    Charge Score: -0.4
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96T58 NP_055816.2 3664 402248 S2918 K P E P I H L S V S T P V T Q
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q62504 3644 398736 S2893 K P E P I H L S V S T P V T Q
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514992 1879 199498 K1165 Q E R P S L D K P E A S H L A
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8SX83 5560 599981 P4642 A P V S V A A P V T V P V P A
Honey Bee Apis mellifera XP_395705 4346 474873 R3436 A N T R K S R R L A E R D G I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784255 4378 488332 S3550 R Q Q R P R K S R R D S G P E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. N.A. N.A. 81.1 N.A. N.A. 30 N.A. N.A. N.A. N.A. 22.1 22.8 N.A. 20.7
Protein Similarity: 100 N.A. N.A. N.A. N.A. 87 N.A. N.A. 37.8 N.A. N.A. N.A. N.A. 35.9 38.4 N.A. 37.9
P-Site Identity: 100 N.A. N.A. N.A. N.A. 100 N.A. N.A. 6.6 N.A. N.A. N.A. N.A. 26.6 0 N.A. 6.6
P-Site Similarity: 100 N.A. N.A. N.A. N.A. 100 N.A. N.A. 13.3 N.A. N.A. N.A. N.A. 40 13.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 34 0 0 0 0 17 17 0 0 17 17 0 0 0 34 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 17 0 0 0 17 0 17 0 0 % D
% Glu: 0 17 34 0 0 0 0 0 0 17 17 0 0 0 17 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 17 17 0 % G
% His: 0 0 0 0 0 34 0 0 0 0 0 0 17 0 0 % H
% Ile: 0 0 0 0 34 0 0 0 0 0 0 0 0 0 17 % I
% Lys: 34 0 0 0 17 0 17 17 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 17 34 0 17 0 0 0 0 17 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 50 0 50 17 0 0 17 17 0 0 50 0 34 0 % P
% Gln: 17 17 17 0 0 0 0 0 0 0 0 0 0 0 34 % Q
% Arg: 17 0 17 34 0 17 17 17 17 17 0 17 0 0 0 % R
% Ser: 0 0 0 17 17 17 0 50 0 34 0 34 0 0 0 % S
% Thr: 0 0 17 0 0 0 0 0 0 17 34 0 0 34 0 % T
% Val: 0 0 17 0 17 0 0 0 50 0 17 0 50 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _