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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNKP All Species: 15.15
Human Site: S143 Identified Species: 30.3
UniProt: Q96T60 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96T60 NP_009185.2 521 57076 S143 P K K R M R K S N P G W E N L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001115581 521 57143 S143 P K K R M R K S N P G W E N L
Dog Lupus familis XP_541488 521 57419 S143 Q K K R M R K S S P G W E N F
Cat Felis silvestris
Mouse Mus musculus Q9JLV6 522 57205 S142 Q K K R V R K S S L G W E S L
Rat Rattus norvegicus Q8K4H4 329 37701
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q7T287 347 39626 K12 W L V S K D G K H G R I R L P
Zebra Danio Brachydanio rerio P61799 324 36503
Tiger Blowfish Takifugu rubipres P61800 356 40172 H20 H K P I L L P H L Q A V V L G
Fruit Fly Dros. melanogaster NP_649792 523 58549 E142 L S P S E K S E R W D S S G N
Honey Bee Apis mellifera XP_624633 492 57193 V137 L I Y T A K G V E N R S M I A
Nematode Worm Caenorhab. elegans Q19683 407 46169 P72 T K S G K V F P T N C Q D W Q
Sea Urchin Strong. purpuratus XP_785301 905 98367 T441 S K K I K K E T K P S E D D I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 96.7 86.5 N.A. 80.8 21.3 N.A. N.A. N.A. 20.9 20.3 21.6 39 36.6 36.8 31.2
Protein Similarity: 100 N.A. 98 90.7 N.A. 88.3 35.1 N.A. N.A. N.A. 36.2 33.9 37 55.8 54.3 50.4 41.5
P-Site Identity: 100 N.A. 100 80 N.A. 66.6 0 N.A. N.A. N.A. 0 0 6.6 0 0 6.6 20
P-Site Similarity: 100 N.A. 100 86.6 N.A. 86.6 0 N.A. N.A. N.A. 6.6 0 13.3 6.6 6.6 13.3 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 0 0 0 9 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % C
% Asp: 0 0 0 0 0 9 0 0 0 0 9 0 17 9 0 % D
% Glu: 0 0 0 0 9 0 9 9 9 0 0 9 34 0 0 % E
% Phe: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 9 % F
% Gly: 0 0 0 9 0 0 17 0 0 9 34 0 0 9 9 % G
% His: 9 0 0 0 0 0 0 9 9 0 0 0 0 0 0 % H
% Ile: 0 9 0 17 0 0 0 0 0 0 0 9 0 9 9 % I
% Lys: 0 59 42 0 25 25 34 9 9 0 0 0 0 0 0 % K
% Leu: 17 9 0 0 9 9 0 0 9 9 0 0 0 17 25 % L
% Met: 0 0 0 0 25 0 0 0 0 0 0 0 9 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 17 17 0 0 0 25 9 % N
% Pro: 17 0 17 0 0 0 9 9 0 34 0 0 0 0 9 % P
% Gln: 17 0 0 0 0 0 0 0 0 9 0 9 0 0 9 % Q
% Arg: 0 0 0 34 0 34 0 0 9 0 17 0 9 0 0 % R
% Ser: 9 9 9 17 0 0 9 34 17 0 9 17 9 9 0 % S
% Thr: 9 0 0 9 0 0 0 9 9 0 0 0 0 0 0 % T
% Val: 0 0 9 0 9 9 0 9 0 0 0 9 9 0 0 % V
% Trp: 9 0 0 0 0 0 0 0 0 9 0 34 0 9 0 % W
% Tyr: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _