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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TCF12 All Species: 14.85
Human Site: S345 Identified Species: 32.67
UniProt: Q99081 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99081 NP_003196.1 682 72965 S345 A L G K A L A S I Y S P D H T
Chimpanzee Pan troglodytes XP_510436 706 75888 S345 A L G K A L A S I Y S P D H T
Rhesus Macaque Macaca mulatta XP_001084466 821 88777 D485 L A S I Y S P D H T N N S F S
Dog Lupus familis XP_542197 632 64907 Y339 G K A L A S I Y S P D H S S N
Cat Felis silvestris
Mouse Mus musculus Q61286 706 75765 S345 A L G K A L A S I Y S P D H T
Rat Rattus norvegicus P51514 707 75878 S345 A L G K A L A S I Y S P D H T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514036 657 70162 Q350 S P L T G A S Q W P R P G G Q
Chicken Gallus gallus P30985 657 70524 L341 S P N Y E N S L H S L K N R V
Frog Xenopus laevis Q01978 658 70072 N336 S P D H S S T N F S S T P S T
Zebra Danio Brachydanio rerio NP_999981 533 56737 D252 S R M E D R L D R L D D A I H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P11420 710 73846 S342 S V L N G G P S S S Y A S E M
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.8 51.7 50.4 N.A. 92 92.3 N.A. 73.1 84 52.9 43.2 N.A. 25.3 N.A. N.A. N.A.
Protein Similarity: 100 96.4 65.4 63.2 N.A. 94.4 94.6 N.A. 79.6 87.3 68.6 54.9 N.A. 40 N.A. N.A. N.A.
P-Site Identity: 100 100 0 6.6 N.A. 100 100 N.A. 6.6 0 13.3 0 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 13.3 6.6 N.A. 100 100 N.A. 20 20 33.3 13.3 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 37 10 10 0 46 10 37 0 0 0 0 10 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 0 10 0 0 19 0 0 19 10 37 0 0 % D
% Glu: 0 0 0 10 10 0 0 0 0 0 0 0 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 10 0 0 0 0 10 0 % F
% Gly: 10 0 37 0 19 10 0 0 0 0 0 0 10 10 0 % G
% His: 0 0 0 10 0 0 0 0 19 0 0 10 0 37 10 % H
% Ile: 0 0 0 10 0 0 10 0 37 0 0 0 0 10 0 % I
% Lys: 0 10 0 37 0 0 0 0 0 0 0 10 0 0 0 % K
% Leu: 10 37 19 10 0 37 10 10 0 10 10 0 0 0 0 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 10 % M
% Asn: 0 0 10 10 0 10 0 10 0 0 10 10 10 0 10 % N
% Pro: 0 28 0 0 0 0 19 0 0 19 0 46 10 0 0 % P
% Gln: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 10 % Q
% Arg: 0 10 0 0 0 10 0 0 10 0 10 0 0 10 0 % R
% Ser: 46 0 10 0 10 28 19 46 19 28 46 0 28 19 10 % S
% Thr: 0 0 0 10 0 0 10 0 0 10 0 10 0 0 46 % T
% Val: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 10 0 0 10 0 37 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _