KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TCF12
All Species:
11.82
Human Site:
S374
Identified Species:
26
UniProt:
Q99081
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99081
NP_003196.1
682
72965
S374
P
S
P
L
T
G
T
S
Q
W
P
R
P
G
G
Chimpanzee
Pan troglodytes
XP_510436
706
75888
S374
P
S
P
L
T
G
T
S
Q
W
P
R
P
G
G
Rhesus Macaque
Macaca mulatta
XP_001084466
821
88777
R514
A
G
T
A
V
W
S
R
N
G
G
Q
A
S
S
Dog
Lupus familis
XP_542197
632
64907
W368
G
L
A
G
T
S
Q
W
P
R
P
G
A
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q61286
706
75765
S374
P
S
P
L
T
G
T
S
Q
W
P
R
A
G
G
Rat
Rattus norvegicus
P51514
707
75878
T374
P
S
P
L
T
A
G
T
S
Q
W
P
R
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514036
657
70162
L379
K
N
R
V
E
Q
Q
L
H
E
H
L
Q
D
A
Chicken
Gallus gallus
P30985
657
70524
S370
L
K
D
V
C
E
Q
S
R
M
E
D
R
L
D
Frog
Xenopus laevis
Q01978
658
70072
A365
P
R
A
N
G
P
G
A
L
S
P
S
Y
D
G
Zebra Danio
Brachydanio rerio
NP_999981
533
56737
G281
N
D
I
H
S
L
L
G
Q
A
H
N
G
P
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P11420
710
73846
L371
G
V
R
M
E
E
R
L
D
D
A
L
N
V
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.8
51.7
50.4
N.A.
92
92.3
N.A.
73.1
84
52.9
43.2
N.A.
25.3
N.A.
N.A.
N.A.
Protein Similarity:
100
96.4
65.4
63.2
N.A.
94.4
94.6
N.A.
79.6
87.3
68.6
54.9
N.A.
40
N.A.
N.A.
N.A.
P-Site Identity:
100
100
0
20
N.A.
93.3
40
N.A.
0
6.6
20
6.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
13.3
20
N.A.
93.3
46.6
N.A.
13.3
20
26.6
13.3
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
19
10
0
10
0
10
0
10
10
0
28
10
10
% A
% Cys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
10
0
0
0
0
0
10
10
0
10
0
19
10
% D
% Glu:
0
0
0
0
19
19
0
0
0
10
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
19
10
0
10
10
28
19
10
0
10
10
10
10
28
55
% G
% His:
0
0
0
10
0
0
0
0
10
0
19
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
10
% I
% Lys:
10
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
10
0
37
0
10
10
19
10
0
0
19
0
10
10
% L
% Met:
0
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
10
10
0
10
0
0
0
0
10
0
0
10
10
0
0
% N
% Pro:
46
0
37
0
0
10
0
0
10
0
46
10
19
19
0
% P
% Gln:
0
0
0
0
0
10
28
0
37
10
0
10
10
0
0
% Q
% Arg:
0
10
19
0
0
0
10
10
10
10
0
28
19
0
0
% R
% Ser:
0
37
0
0
10
10
10
37
10
10
0
10
0
10
10
% S
% Thr:
0
0
10
0
46
0
28
10
0
0
0
0
0
0
0
% T
% Val:
0
10
0
19
10
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
10
0
10
0
28
10
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _