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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TCF12
All Species:
10
Human Site:
S395
Identified Species:
22
UniProt:
Q99081
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99081
NP_003196.1
682
72965
S395
S
Y
E
N
S
L
H
S
L
Q
S
R
M
E
D
Chimpanzee
Pan troglodytes
XP_510436
706
75888
S395
S
Y
E
N
S
L
H
S
L
K
N
R
V
E
Q
Rhesus Macaque
Macaca mulatta
XP_001084466
821
88777
R535
P
L
H
S
L
Q
S
R
I
E
D
R
L
E
R
Dog
Lupus familis
XP_542197
632
64907
Q389
D
G
G
L
H
S
L
Q
T
K
M
E
D
H
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61286
706
75765
S395
S
Y
E
N
S
L
H
S
L
K
N
R
V
E
Q
Rat
Rattus norvegicus
P51514
707
75878
H395
P
S
Y
E
N
S
L
H
S
L
K
N
R
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514036
657
70162
E400
V
C
E
Q
S
R
M
E
D
R
L
D
R
L
D
Chicken
Gallus gallus
P30985
657
70524
V391
H
V
L
R
N
H
A
V
G
P
S
T
S
L
S
Frog
Xenopus laevis
Q01978
658
70072
D386
N
K
M
E
D
R
L
D
E
A
I
H
V
L
R
Zebra Danio
Brachydanio rerio
NP_999981
533
56737
T302
F
P
S
S
G
L
V
T
N
R
T
A
Q
M
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P11420
710
73846
Q392
E
M
L
A
G
V
N
Q
S
L
A
S
I
D
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.8
51.7
50.4
N.A.
92
92.3
N.A.
73.1
84
52.9
43.2
N.A.
25.3
N.A.
N.A.
N.A.
Protein Similarity:
100
96.4
65.4
63.2
N.A.
94.4
94.6
N.A.
79.6
87.3
68.6
54.9
N.A.
40
N.A.
N.A.
N.A.
P-Site Identity:
100
73.3
13.3
0
N.A.
73.3
0
N.A.
20
6.6
0
6.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
40
6.6
N.A.
93.3
13.3
N.A.
26.6
13.3
13.3
33.3
N.A.
40
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
10
0
0
10
10
10
0
0
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
10
0
0
10
10
0
10
10
10
10
19
% D
% Glu:
10
0
37
19
0
0
0
10
10
10
0
10
0
37
10
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
10
0
19
0
0
0
10
0
0
0
0
0
10
% G
% His:
10
0
10
0
10
10
28
10
0
0
0
10
0
10
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
10
0
10
0
0
% I
% Lys:
0
10
0
0
0
0
0
0
0
28
10
0
0
0
0
% K
% Leu:
0
10
19
10
10
37
28
0
28
19
10
0
10
28
10
% L
% Met:
0
10
10
0
0
0
10
0
0
0
10
0
10
10
0
% M
% Asn:
10
0
0
28
19
0
10
0
10
0
19
10
0
0
10
% N
% Pro:
19
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% P
% Gln:
0
0
0
10
0
10
0
19
0
10
0
0
10
0
19
% Q
% Arg:
0
0
0
10
0
19
0
10
0
19
0
37
19
0
19
% R
% Ser:
28
10
10
19
37
19
10
28
19
0
19
10
10
0
10
% S
% Thr:
0
0
0
0
0
0
0
10
10
0
10
10
0
0
0
% T
% Val:
10
10
0
0
0
10
10
10
0
0
0
0
28
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
28
10
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _