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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH4
All Species:
25.76
Human Site:
S1645
Identified Species:
47.22
UniProt:
Q99466
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99466
NP_004548.3
2003
209622
S1645
L
H
L
A
A
R
F
S
R
P
T
A
A
R
R
Chimpanzee
Pan troglodytes
XP_518380
2003
209553
S1640
L
H
L
A
A
R
F
S
R
P
T
A
A
R
R
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S1888
L
H
L
A
A
R
Y
S
R
A
D
A
A
K
R
Dog
Lupus familis
XP_538847
1778
185807
K1503
G
E
D
S
I
R
L
K
A
L
K
P
E
A
E
Cat
Felis silvestris
Mouse
Mus musculus
P31695
1964
206674
S1640
L
H
L
A
A
R
F
S
R
P
T
A
A
R
R
Rat
Rattus norvegicus
Q07008
2531
270981
S1929
L
H
L
A
A
R
Y
S
R
S
D
A
A
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
S1884
L
H
L
A
A
R
Y
S
R
A
D
A
A
K
R
Chicken
Gallus gallus
XP_415420
2590
279561
S1978
L
H
L
A
A
R
Y
S
R
S
D
A
A
K
R
Frog
Xenopus laevis
P21783
2524
275106
A1936
L
H
L
A
A
R
Y
A
R
A
D
A
A
K
R
Zebra Danio
Brachydanio rerio
P46530
2437
262289
A1927
L
H
L
A
A
R
Y
A
R
S
D
A
A
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
A1962
L
H
L
A
A
R
F
A
R
A
D
A
A
K
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
D1155
N
S
T
K
L
K
G
D
I
E
E
L
D
R
N
Sea Urchin
Strong. purpuratus
P10079
1064
112055
S790
T
D
I
D
E
C
A
S
A
P
C
Q
N
G
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
33.6
78.1
N.A.
80.1
34
N.A.
33.4
34.4
33.4
35.9
N.A.
30.2
N.A.
22.9
23.4
Protein Similarity:
100
99.3
46.5
81.7
N.A.
85.7
45.9
N.A.
45.4
45.8
46
47.7
N.A.
40.6
N.A.
36
32
P-Site Identity:
100
100
73.3
6.6
N.A.
100
73.3
N.A.
73.3
73.3
66.6
66.6
N.A.
73.3
N.A.
6.6
13.3
P-Site Similarity:
100
100
86.6
13.3
N.A.
100
86.6
N.A.
86.6
86.6
86.6
86.6
N.A.
86.6
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
77
77
0
8
24
16
31
0
77
77
8
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
8
8
8
0
0
0
8
0
0
54
0
8
0
0
% D
% Glu:
0
8
0
0
8
0
0
0
0
8
8
0
8
0
8
% E
% Phe:
0
0
0
0
0
0
31
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
8
0
0
0
0
0
0
8
8
% G
% His:
0
77
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
8
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
0
8
0
8
0
0
8
0
0
54
0
% K
% Leu:
77
0
77
0
8
0
8
0
0
8
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
31
0
8
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
85
0
0
77
0
0
0
0
31
77
% R
% Ser:
0
8
0
8
0
0
0
62
0
24
0
0
0
0
0
% S
% Thr:
8
0
8
0
0
0
0
0
0
0
24
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
47
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _