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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH4 All Species: 6.36
Human Site: S1847 Identified Species: 11.67
UniProt: Q99466 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99466 NP_004548.3 2003 209622 S1847 F P R A R T V S V S V P P H G
Chimpanzee Pan troglodytes XP_518380 2003 209553 S1842 F P L A R T V S V S V P P H G
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 T2164 P H T Y V S D T T S S P M I T
Dog Lupus familis XP_538847 1778 185807 L1641 R P T A A R R L L E A G A N P
Cat Felis silvestris
Mouse Mus musculus P31695 1964 206674 D1809 A R Q R S H W D L L T L L E G
Rat Rattus norvegicus Q07008 2531 270981 H2231 L P G M P D T H L G I S H L N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 E2141 G E K G Q L S E S S V T L S P
Chicken Gallus gallus XP_415420 2590 279561 P2268 F Q Q S P S M P L N H L P G M
Frog Xenopus laevis P21783 2524 275106 S2118 D E Y N L V K S P T L H N G P
Zebra Danio Brachydanio rerio P46530 2437 262289 A2247 R L S H L P V A N N V G G A Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 K2235 K K T S A A S K K A A N L N G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 I1292 N H H N I V D I F D R C R P E
Sea Urchin Strong. purpuratus P10079 1064 112055 G927 Y T C Q C R L G Y I G V N C E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 33.6 78.1 N.A. 80.1 34 N.A. 33.4 34.4 33.4 35.9 N.A. 30.2 N.A. 22.9 23.4
Protein Similarity: 100 99.3 46.5 81.7 N.A. 85.7 45.9 N.A. 45.4 45.8 46 47.7 N.A. 40.6 N.A. 36 32
P-Site Identity: 100 93.3 13.3 13.3 N.A. 6.6 6.6 N.A. 13.3 13.3 6.6 13.3 N.A. 6.6 N.A. 0 0
P-Site Similarity: 100 93.3 26.6 26.6 N.A. 20 20 N.A. 26.6 53.3 20 26.6 N.A. 26.6 N.A. 0 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 24 16 8 0 8 0 8 16 0 8 8 0 % A
% Cys: 0 0 8 0 8 0 0 0 0 0 0 8 0 8 0 % C
% Asp: 8 0 0 0 0 8 16 8 0 8 0 0 0 0 0 % D
% Glu: 0 16 0 0 0 0 0 8 0 8 0 0 0 8 16 % E
% Phe: 24 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % F
% Gly: 8 0 8 8 0 0 0 8 0 8 8 16 8 16 31 % G
% His: 0 16 8 8 0 8 0 8 0 0 8 8 8 16 0 % H
% Ile: 0 0 0 0 8 0 0 8 0 8 8 0 0 8 0 % I
% Lys: 8 8 8 0 0 0 8 8 8 0 0 0 0 0 0 % K
% Leu: 8 8 8 0 16 8 8 8 31 8 8 16 24 8 0 % L
% Met: 0 0 0 8 0 0 8 0 0 0 0 0 8 0 8 % M
% Asn: 8 0 0 16 0 0 0 0 8 16 0 8 16 16 8 % N
% Pro: 8 31 0 0 16 8 0 8 8 0 0 24 24 8 24 % P
% Gln: 0 8 16 8 8 0 0 0 0 0 0 0 0 0 8 % Q
% Arg: 16 8 8 8 16 16 8 0 0 0 8 0 8 0 0 % R
% Ser: 0 0 8 16 8 16 16 24 8 31 8 8 0 8 0 % S
% Thr: 0 8 24 0 0 16 8 8 8 8 8 8 0 0 8 % T
% Val: 0 0 0 0 8 16 24 0 16 0 31 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 8 8 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _