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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH4
All Species:
8.79
Human Site:
S1895
Identified Species:
16.11
UniProt:
Q99466
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99466
NP_004548.3
2003
209622
S1895
A
R
G
G
G
A
Y
S
H
C
R
S
L
S
G
Chimpanzee
Pan troglodytes
XP_518380
2003
209553
S1890
A
R
G
G
G
A
Y
S
H
C
R
S
L
S
G
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
T2216
P
L
A
H
G
A
S
T
V
L
P
S
V
S
Q
Dog
Lupus familis
XP_538847
1778
185807
D1688
A
V
D
A
R
T
E
D
G
T
T
A
L
M
L
Cat
Felis silvestris
Mouse
Mus musculus
P31695
1964
206674
L1856
P
R
G
G
G
A
C
L
Q
A
R
T
W
S
V
Rat
Rattus norvegicus
Q07008
2531
270981
M2284
S
T
N
G
T
G
A
M
N
F
T
V
G
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
P2212
P
L
A
R
G
A
G
P
V
L
P
S
V
S
Q
Chicken
Gallus gallus
XP_415420
2590
279561
N2324
S
P
S
T
A
M
S
N
A
P
M
N
F
S
V
Frog
Xenopus laevis
P21783
2524
275106
A2167
K
G
N
G
C
K
E
A
K
E
L
K
A
R
R
Zebra Danio
Brachydanio rerio
P46530
2437
262289
S2302
G
Y
P
T
M
Q
S
S
H
L
G
A
P
S
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
M2304
S
P
Y
D
T
S
S
M
Y
S
N
A
M
A
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
S1339
K
K
E
S
A
S
N
S
R
D
S
T
H
L
T
Sea Urchin
Strong. purpuratus
P10079
1064
112055
A974
Y
M
T
Y
N
E
R
A
L
G
Y
A
A
P
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
33.6
78.1
N.A.
80.1
34
N.A.
33.4
34.4
33.4
35.9
N.A.
30.2
N.A.
22.9
23.4
Protein Similarity:
100
99.3
46.5
81.7
N.A.
85.7
45.9
N.A.
45.4
45.8
46
47.7
N.A.
40.6
N.A.
36
32
P-Site Identity:
100
100
26.6
13.3
N.A.
46.6
6.6
N.A.
26.6
6.6
6.6
20
N.A.
0
N.A.
6.6
0
P-Site Similarity:
100
100
40
20
N.A.
53.3
26.6
N.A.
33.3
26.6
13.3
26.6
N.A.
40
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
16
8
16
39
8
16
8
8
0
31
16
16
8
% A
% Cys:
0
0
0
0
8
0
8
0
0
16
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
0
0
8
0
8
0
0
0
0
0
% D
% Glu:
0
0
8
0
0
8
16
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% F
% Gly:
8
8
24
39
39
8
8
0
8
8
8
0
8
0
16
% G
% His:
0
0
0
8
0
0
0
0
24
0
0
0
8
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
16
8
0
0
0
8
0
0
8
0
0
8
0
0
0
% K
% Leu:
0
16
0
0
0
0
0
8
8
24
8
0
24
8
8
% L
% Met:
0
8
0
0
8
8
0
16
0
0
8
0
8
8
0
% M
% Asn:
0
0
16
0
8
0
8
8
8
0
8
8
0
0
0
% N
% Pro:
24
16
8
0
0
0
0
8
0
8
16
0
8
8
8
% P
% Gln:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
16
% Q
% Arg:
0
24
0
8
8
0
8
0
8
0
24
0
0
8
8
% R
% Ser:
24
0
8
8
0
16
31
31
0
8
8
31
0
54
0
% S
% Thr:
0
8
8
16
16
8
0
8
0
8
16
16
0
0
16
% T
% Val:
0
8
0
0
0
0
0
0
16
0
0
8
16
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
8
8
8
8
0
0
16
0
8
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _