KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH4
All Species:
11.52
Human Site:
S1899
Identified Species:
21.11
UniProt:
Q99466
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99466
NP_004548.3
2003
209622
S1899
G
A
Y
S
H
C
R
S
L
S
G
V
G
A
G
Chimpanzee
Pan troglodytes
XP_518380
2003
209553
S1894
G
A
Y
S
H
C
R
S
L
S
G
V
G
A
G
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2220
G
A
S
T
V
L
P
S
V
S
Q
L
L
S
H
Dog
Lupus familis
XP_538847
1778
185807
A1692
R
T
E
D
G
T
T
A
L
M
L
A
A
R
L
Cat
Felis silvestris
Mouse
Mus musculus
P31695
1964
206674
T1860
G
A
C
L
Q
A
R
T
W
S
V
D
L
G
A
Rat
Rattus norvegicus
Q07008
2531
270981
V2288
T
G
A
M
N
F
T
V
G
A
P
A
S
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
S2216
G
A
G
P
V
L
P
S
V
S
Q
L
L
S
H
Chicken
Gallus gallus
XP_415420
2590
279561
N2328
A
M
S
N
A
P
M
N
F
S
V
G
G
A
A
Frog
Xenopus laevis
P21783
2524
275106
K2171
C
K
E
A
K
E
L
K
A
R
R
K
K
S
Q
Zebra Danio
Brachydanio rerio
P46530
2437
262289
A2306
M
Q
S
S
H
L
G
A
P
S
H
M
I
A
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
A2308
T
S
S
M
Y
S
N
A
M
A
A
P
L
A
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
T1343
A
S
N
S
R
D
S
T
H
L
T
P
P
P
S
Sea Urchin
Strong. purpuratus
P10079
1064
112055
A978
N
E
R
A
L
G
Y
A
A
P
T
V
V
V
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
33.6
78.1
N.A.
80.1
34
N.A.
33.4
34.4
33.4
35.9
N.A.
30.2
N.A.
22.9
23.4
Protein Similarity:
100
99.3
46.5
81.7
N.A.
85.7
45.9
N.A.
45.4
45.8
46
47.7
N.A.
40.6
N.A.
36
32
P-Site Identity:
100
100
26.6
6.6
N.A.
26.6
0
N.A.
26.6
20
0
26.6
N.A.
6.6
N.A.
6.6
13.3
P-Site Similarity:
100
100
53.3
13.3
N.A.
33.3
13.3
N.A.
46.6
33.3
13.3
40
N.A.
40
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
39
8
16
8
8
0
31
16
16
8
16
8
39
16
% A
% Cys:
8
0
8
0
0
16
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
8
0
0
0
0
0
8
0
0
0
% D
% Glu:
0
8
16
0
0
8
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
0
% F
% Gly:
39
8
8
0
8
8
8
0
8
0
16
8
24
8
24
% G
% His:
0
0
0
0
24
0
0
0
8
0
8
0
0
0
24
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
8
0
0
8
0
0
8
0
0
0
8
8
0
0
% K
% Leu:
0
0
0
8
8
24
8
0
24
8
8
16
31
8
8
% L
% Met:
8
8
0
16
0
0
8
0
8
8
0
8
0
0
0
% M
% Asn:
8
0
8
8
8
0
8
8
0
0
0
0
0
0
16
% N
% Pro:
0
0
0
8
0
8
16
0
8
8
8
16
8
8
0
% P
% Gln:
0
8
0
0
8
0
0
0
0
0
16
0
0
0
8
% Q
% Arg:
8
0
8
0
8
0
24
0
0
8
8
0
0
8
0
% R
% Ser:
0
16
31
31
0
8
8
31
0
54
0
0
8
24
8
% S
% Thr:
16
8
0
8
0
8
16
16
0
0
16
0
0
0
0
% T
% Val:
0
0
0
0
16
0
0
8
16
0
16
24
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
16
0
8
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _