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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH4
All Species:
9.39
Human Site:
S1975
Identified Species:
17.22
UniProt:
Q99466
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99466
NP_004548.3
2003
209622
S1975
P
P
P
C
L
T
P
S
P
E
R
G
S
P
Q
Chimpanzee
Pan troglodytes
XP_518380
2003
209553
S1970
P
P
P
C
L
T
P
S
P
E
R
G
S
P
Q
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
N2396
Q
H
S
Y
A
S
S
N
A
A
E
R
T
P
S
Dog
Lupus familis
XP_538847
1778
185807
K1766
R
G
P
H
K
S
N
K
T
G
R
G
S
A
E
Cat
Felis silvestris
Mouse
Mus musculus
P31695
1964
206674
S1936
P
P
P
S
L
T
P
S
P
E
R
G
S
P
Q
Rat
Rattus norvegicus
Q07008
2531
270981
E2412
G
R
S
F
L
S
G
E
P
S
Q
A
D
V
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
L2306
P
P
I
V
T
F
H
L
L
P
K
G
G
G
A
Chicken
Gallus gallus
XP_415420
2590
279561
Q2419
L
Q
N
Q
Q
M
Q
Q
M
Q
Q
P
G
M
Q
Frog
Xenopus laevis
P21783
2524
275106
A2272
P
R
L
T
H
L
N
A
S
S
P
N
T
I
M
Zebra Danio
Brachydanio rerio
P46530
2437
262289
V2388
N
T
P
N
H
Q
Q
V
P
D
H
P
F
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
H2433
S
S
L
A
L
S
P
H
A
Y
L
G
S
P
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
E1417
S
Y
T
Q
M
Q
N
E
P
M
T
R
Y
S
E
Sea Urchin
Strong. purpuratus
P10079
1064
112055
T1052
M
V
G
Q
D
K
W
T
R
Y
E
Q
S
I
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
33.6
78.1
N.A.
80.1
34
N.A.
33.4
34.4
33.4
35.9
N.A.
30.2
N.A.
22.9
23.4
Protein Similarity:
100
99.3
46.5
81.7
N.A.
85.7
45.9
N.A.
45.4
45.8
46
47.7
N.A.
40.6
N.A.
36
32
P-Site Identity:
100
100
6.6
26.6
N.A.
93.3
20
N.A.
20
6.6
6.6
13.3
N.A.
33.3
N.A.
6.6
6.6
P-Site Similarity:
100
100
26.6
40
N.A.
93.3
33.3
N.A.
26.6
20
20
20
N.A.
40
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
8
16
8
0
8
0
8
16
% A
% Cys:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
8
0
0
8
0
0
% D
% Glu:
0
0
0
0
0
0
0
16
0
24
16
0
0
0
16
% E
% Phe:
0
0
0
8
0
8
0
0
0
0
0
0
8
0
0
% F
% Gly:
8
8
8
0
0
0
8
0
0
8
0
47
16
8
0
% G
% His:
0
8
0
8
16
0
8
8
0
0
8
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
0
0
0
16
0
% I
% Lys:
0
0
0
0
8
8
0
8
0
0
8
0
0
0
0
% K
% Leu:
8
0
16
0
39
8
0
8
8
0
8
0
0
8
0
% L
% Met:
8
0
0
0
8
8
0
0
8
8
0
0
0
8
8
% M
% Asn:
8
0
8
8
0
0
24
8
0
0
0
8
0
0
0
% N
% Pro:
39
31
39
0
0
0
31
0
47
8
8
16
0
39
0
% P
% Gln:
8
8
0
24
8
16
16
8
0
8
16
8
0
0
39
% Q
% Arg:
8
16
0
0
0
0
0
0
8
0
31
16
0
0
0
% R
% Ser:
16
8
16
8
0
31
8
24
8
16
0
0
47
8
16
% S
% Thr:
0
8
8
8
8
24
0
8
8
0
8
0
16
0
8
% T
% Val:
0
8
0
8
0
0
0
8
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
8
0
0
0
0
0
16
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _