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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH4 All Species: 14.24
Human Site: S1980 Identified Species: 26.11
UniProt: Q99466 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99466 NP_004548.3 2003 209622 S1980 T P S P E R G S P Q L D C G P
Chimpanzee Pan troglodytes XP_518380 2003 209553 S1975 T P S P E R G S P Q L D C G S
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 T2401 S S N A A E R T P S H S G H L
Dog Lupus familis XP_538847 1778 185807 S1771 S N K T G R G S A E S A E S L
Cat Felis silvestris
Mouse Mus musculus P31695 1964 206674 S1941 T P S P E R G S P Q V A W G L
Rat Rattus norvegicus Q07008 2531 270981 D2417 S G E P S Q A D V Q P L G P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 G2311 F H L L P K G G G A Q A A G L
Chicken Gallus gallus XP_415420 2590 279561 G2424 M Q Q M Q Q P G M Q P Q P G M
Frog Xenopus laevis P21783 2524 275106 T2277 L N A S S P N T I M S N G S M
Zebra Danio Brachydanio rerio P46530 2437 262289 F2393 Q Q V P D H P F L T P S A G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 S2438 S P H A Y L G S P S P A K S R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 Y1422 Q N E P M T R Y S E P A H Y F
Sea Urchin Strong. purpuratus P10079 1064 112055 S1057 K W T R Y E Q S I A P Q P D A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 33.6 78.1 N.A. 80.1 34 N.A. 33.4 34.4 33.4 35.9 N.A. 30.2 N.A. 22.9 23.4
Protein Similarity: 100 99.3 46.5 81.7 N.A. 85.7 45.9 N.A. 45.4 45.8 46 47.7 N.A. 40.6 N.A. 36 32
P-Site Identity: 100 93.3 6.6 20 N.A. 73.3 13.3 N.A. 13.3 13.3 0 13.3 N.A. 26.6 N.A. 6.6 6.6
P-Site Similarity: 100 93.3 26.6 33.3 N.A. 80 26.6 N.A. 20 26.6 20 20 N.A. 33.3 N.A. 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 16 8 0 8 0 8 16 0 39 16 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 16 0 0 % C
% Asp: 0 0 0 0 8 0 0 8 0 0 0 16 0 8 0 % D
% Glu: 0 0 16 0 24 16 0 0 0 16 0 0 8 0 0 % E
% Phe: 8 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % F
% Gly: 0 8 0 0 8 0 47 16 8 0 0 0 24 47 0 % G
% His: 0 8 8 0 0 8 0 0 0 0 8 0 8 8 0 % H
% Ile: 0 0 0 0 0 0 0 0 16 0 0 0 0 0 0 % I
% Lys: 8 0 8 0 0 8 0 0 0 0 0 0 8 0 0 % K
% Leu: 8 0 8 8 0 8 0 0 8 0 16 8 0 0 31 % L
% Met: 8 0 0 8 8 0 0 0 8 8 0 0 0 0 16 % M
% Asn: 0 24 8 0 0 0 8 0 0 0 0 8 0 0 0 % N
% Pro: 0 31 0 47 8 8 16 0 39 0 47 0 16 8 8 % P
% Gln: 16 16 8 0 8 16 8 0 0 39 8 16 0 0 0 % Q
% Arg: 0 0 0 8 0 31 16 0 0 0 0 0 0 0 8 % R
% Ser: 31 8 24 8 16 0 0 47 8 16 16 16 0 24 24 % S
% Thr: 24 0 8 8 0 8 0 16 0 8 0 0 0 0 0 % T
% Val: 0 0 8 0 0 0 0 0 8 0 8 0 0 0 0 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 16 0 0 8 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _