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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH4
All Species:
8.18
Human Site:
T1493
Identified Species:
15
UniProt:
Q99466
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99466
NP_004548.3
2003
209622
T1493
G
F
T
R
R
P
R
T
Q
S
A
P
H
R
R
Chimpanzee
Pan troglodytes
XP_518380
2003
209553
T1491
G
F
T
R
R
P
R
T
Q
S
A
P
H
R
R
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
R1719
P
E
G
F
T
L
R
R
D
A
S
N
H
K
R
Dog
Lupus familis
XP_538847
1778
185807
L1368
V
G
K
E
T
D
S
L
S
T
G
F
V
V
V
Cat
Felis silvestris
Mouse
Mus musculus
P31695
1964
206674
A1489
G
F
I
R
R
P
Q
A
Q
Q
A
P
H
R
R
Rat
Rattus norvegicus
Q07008
2531
270981
S1766
F
P
E
G
F
K
V
S
E
A
S
K
K
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
R1715
P
E
G
F
V
L
R
R
D
S
S
N
H
K
R
Chicken
Gallus gallus
XP_415420
2590
279561
T1814
F
P
E
G
F
K
V
T
E
S
S
K
K
K
R
Frog
Xenopus laevis
P21783
2524
275106
K1770
F
P
D
G
F
I
P
K
E
P
S
K
K
K
R
Zebra Danio
Brachydanio rerio
P46530
2437
262289
V1766
W
F
P
E
G
F
K
V
N
E
P
K
K
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
A1786
E
G
F
R
A
P
A
A
V
M
S
R
R
R
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
P1020
Q
I
P
T
E
P
E
P
E
S
P
I
K
L
H
Sea Urchin
Strong. purpuratus
P10079
1064
112055
V655
V
D
Q
V
N
S
Y
V
C
F
C
L
P
G
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
33.6
78.1
N.A.
80.1
34
N.A.
33.4
34.4
33.4
35.9
N.A.
30.2
N.A.
22.9
23.4
Protein Similarity:
100
99.3
46.5
81.7
N.A.
85.7
45.9
N.A.
45.4
45.8
46
47.7
N.A.
40.6
N.A.
36
32
P-Site Identity:
100
100
20
0
N.A.
73.3
6.6
N.A.
26.6
20
6.6
13.3
N.A.
26.6
N.A.
13.3
0
P-Site Similarity:
100
100
40
6.6
N.A.
80
40
N.A.
40
40
26.6
26.6
N.A.
33.3
N.A.
20
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
8
16
0
16
24
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% C
% Asp:
0
8
8
0
0
8
0
0
16
0
0
0
0
0
0
% D
% Glu:
8
16
16
16
8
0
8
0
31
8
0
0
0
0
0
% E
% Phe:
24
31
8
16
24
8
0
0
0
8
0
8
0
0
8
% F
% Gly:
24
16
16
24
8
0
0
0
0
0
8
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
39
0
8
% H
% Ile:
0
8
8
0
0
8
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
8
0
0
16
8
8
0
0
0
31
39
47
0
% K
% Leu:
0
0
0
0
0
16
0
8
0
0
0
8
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
8
0
0
16
0
0
0
% N
% Pro:
16
24
16
0
0
39
8
8
0
8
16
24
8
0
0
% P
% Gln:
8
0
8
0
0
0
8
0
24
8
0
0
0
0
0
% Q
% Arg:
0
0
0
31
24
0
31
16
0
0
0
8
8
31
77
% R
% Ser:
0
0
0
0
0
8
8
8
8
39
47
0
0
0
0
% S
% Thr:
0
0
16
8
16
0
0
24
0
8
0
0
0
0
0
% T
% Val:
16
0
0
8
8
0
16
16
8
0
0
0
8
8
8
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _