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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH4
All Species:
9.39
Human Site:
T1832
Identified Species:
17.22
UniProt:
Q99466
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99466
NP_004548.3
2003
209622
T1832
P
E
A
R
H
K
A
T
P
G
R
E
A
G
P
Chimpanzee
Pan troglodytes
XP_518380
2003
209553
T1827
P
E
A
R
H
K
A
T
P
G
R
E
A
G
P
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2149
S
E
S
S
V
T
L
S
P
V
D
S
L
E
S
Dog
Lupus familis
XP_538847
1778
185807
L1626
V
G
T
G
E
T
P
L
H
L
A
A
R
F
S
Cat
Felis silvestris
Mouse
Mus musculus
P31695
1964
206674
A1794
A
R
G
L
R
D
Q
A
G
L
A
P
G
D
V
Rat
Rattus norvegicus
Q07008
2531
270981
S2216
L
P
S
P
F
Q
Q
S
P
S
M
P
L
S
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
G2126
E
P
K
D
P
R
S
G
G
R
R
K
K
N
L
Chicken
Gallus gallus
XP_415420
2590
279561
S2253
G
Y
L
S
D
V
A
S
P
P
L
M
T
S
P
Frog
Xenopus laevis
P21783
2524
275106
H2103
D
I
A
Q
E
R
M
H
H
D
I
V
H
L
L
Zebra Danio
Brachydanio rerio
P46530
2437
262289
G2232
G
G
A
L
Q
G
L
G
K
P
F
D
S
A
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
S2220
N
G
L
D
A
T
G
S
L
R
R
K
A
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
A1277
V
D
A
T
D
H
T
A
R
Q
L
A
Q
A
N
Sea Urchin
Strong. purpuratus
P10079
1064
112055
L912
L
P
C
Q
N
G
G
L
C
I
D
G
I
A
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
33.6
78.1
N.A.
80.1
34
N.A.
33.4
34.4
33.4
35.9
N.A.
30.2
N.A.
22.9
23.4
Protein Similarity:
100
99.3
46.5
81.7
N.A.
85.7
45.9
N.A.
45.4
45.8
46
47.7
N.A.
40.6
N.A.
36
32
P-Site Identity:
100
100
13.3
0
N.A.
0
6.6
N.A.
6.6
20
6.6
13.3
N.A.
13.3
N.A.
6.6
0
P-Site Similarity:
100
100
26.6
0
N.A.
0
26.6
N.A.
26.6
26.6
20
26.6
N.A.
26.6
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
39
0
8
0
24
16
0
0
16
16
24
24
0
% A
% Cys:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
8
8
0
16
16
8
0
0
0
8
16
8
0
8
0
% D
% Glu:
8
24
0
0
16
0
0
0
0
0
0
16
0
8
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
8
0
0
8
0
% F
% Gly:
16
24
8
8
0
16
16
16
16
16
0
8
8
16
8
% G
% His:
0
0
0
0
16
8
0
8
16
0
0
0
8
0
8
% H
% Ile:
0
8
0
0
0
0
0
0
0
8
8
0
8
0
0
% I
% Lys:
0
0
8
0
0
16
0
0
8
0
0
16
8
0
0
% K
% Leu:
16
0
16
16
0
0
16
16
8
16
16
0
16
8
16
% L
% Met:
0
0
0
0
0
0
8
0
0
0
8
8
0
0
0
% M
% Asn:
8
0
0
0
8
0
0
0
0
0
0
0
0
8
8
% N
% Pro:
16
24
0
8
8
0
8
0
39
16
0
16
0
0
31
% P
% Gln:
0
0
0
16
8
8
16
0
0
8
0
0
8
0
0
% Q
% Arg:
0
8
0
16
8
16
0
0
8
16
31
0
8
0
0
% R
% Ser:
8
0
16
16
0
0
8
31
0
8
0
8
8
24
24
% S
% Thr:
0
0
8
8
0
24
8
16
0
0
0
0
8
0
0
% T
% Val:
16
0
0
0
8
8
0
0
0
8
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _