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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH4
All Species:
8.18
Human Site:
T1845
Identified Species:
15
UniProt:
Q99466
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99466
NP_004548.3
2003
209622
T1845
G
P
F
P
R
A
R
T
V
S
V
S
V
P
P
Chimpanzee
Pan troglodytes
XP_518380
2003
209553
T1840
G
P
F
P
L
A
R
T
V
S
V
S
V
P
P
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2162
E
S
P
H
T
Y
V
S
D
T
T
S
S
P
M
Dog
Lupus familis
XP_538847
1778
185807
R1639
F
S
R
P
T
A
A
R
R
L
L
E
A
G
A
Cat
Felis silvestris
Mouse
Mus musculus
P31695
1964
206674
H1807
D
V
A
R
Q
R
S
H
W
D
L
L
T
L
L
Rat
Rattus norvegicus
Q07008
2531
270981
D2229
S
H
L
P
G
M
P
D
T
H
L
G
I
S
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
L2139
N
L
G
E
K
G
Q
L
S
E
S
S
V
T
L
Chicken
Gallus gallus
XP_415420
2590
279561
S2266
S
P
F
Q
Q
S
P
S
M
P
L
N
H
L
P
Frog
Xenopus laevis
P21783
2524
275106
V2116
L
L
D
E
Y
N
L
V
K
S
P
T
L
H
N
Zebra Danio
Brachydanio rerio
P46530
2437
262289
P2245
A
P
R
L
S
H
L
P
V
A
N
N
V
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
A2233
S
S
K
K
T
S
A
A
S
K
K
A
A
N
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
V1290
A
N
N
H
H
N
I
V
D
I
F
D
R
C
R
Sea Urchin
Strong. purpuratus
P10079
1064
112055
R925
A
G
Y
T
C
Q
C
R
L
G
Y
I
G
V
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
33.6
78.1
N.A.
80.1
34
N.A.
33.4
34.4
33.4
35.9
N.A.
30.2
N.A.
22.9
23.4
Protein Similarity:
100
99.3
46.5
81.7
N.A.
85.7
45.9
N.A.
45.4
45.8
46
47.7
N.A.
40.6
N.A.
36
32
P-Site Identity:
100
93.3
13.3
13.3
N.A.
0
6.6
N.A.
13.3
20
6.6
20
N.A.
0
N.A.
0
0
P-Site Similarity:
100
93.3
26.6
20
N.A.
13.3
20
N.A.
26.6
60
20
33.3
N.A.
13.3
N.A.
0
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
8
0
0
24
16
8
0
8
0
8
16
0
8
% A
% Cys:
0
0
0
0
8
0
8
0
0
0
0
0
0
8
0
% C
% Asp:
8
0
8
0
0
0
0
8
16
8
0
8
0
0
0
% D
% Glu:
8
0
0
16
0
0
0
0
0
8
0
8
0
0
0
% E
% Phe:
8
0
24
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
16
8
8
0
8
8
0
0
0
8
0
8
8
16
8
% G
% His:
0
8
0
16
8
8
0
8
0
8
0
0
8
8
8
% H
% Ile:
0
0
0
0
0
0
8
0
0
8
0
8
8
0
0
% I
% Lys:
0
0
8
8
8
0
0
0
8
8
8
0
0
0
0
% K
% Leu:
8
16
8
8
8
0
16
8
8
8
31
8
8
16
24
% L
% Met:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
8
% M
% Asn:
8
8
8
0
0
16
0
0
0
0
8
16
0
8
16
% N
% Pro:
0
31
8
31
0
0
16
8
0
8
8
0
0
24
24
% P
% Gln:
0
0
0
8
16
8
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
16
8
8
8
16
16
8
0
0
0
8
0
8
% R
% Ser:
24
24
0
0
8
16
8
16
16
24
8
31
8
8
0
% S
% Thr:
0
0
0
8
24
0
0
16
8
8
8
8
8
8
0
% T
% Val:
0
8
0
0
0
0
8
16
24
0
16
0
31
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
8
8
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _