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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH4 All Species: 10.91
Human Site: Y1894 Identified Species: 20
UniProt: Q99466 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99466 NP_004548.3 2003 209622 Y1894 A A R G G G A Y S H C R S L S
Chimpanzee Pan troglodytes XP_518380 2003 209553 Y1889 A A R G G G A Y S H C R S L S
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 S2215 Q P L A H G A S T V L P S V S
Dog Lupus familis XP_538847 1778 185807 E1687 T A V D A R T E D G T T A L M
Cat Felis silvestris
Mouse Mus musculus P31695 1964 206674 C1855 R P R G G G A C L Q A R T W S
Rat Rattus norvegicus Q07008 2531 270981 A2283 L S T N G T G A M N F T V G A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 G2211 Q P L A R G A G P V L P S V S
Chicken Gallus gallus XP_415420 2590 279561 S2323 S S P S T A M S N A P M N F S
Frog Xenopus laevis P21783 2524 275106 E2166 I K G N G C K E A K E L K A R
Zebra Danio Brachydanio rerio P46530 2437 262289 S2301 M G Y P T M Q S S H L G A P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 S2303 P S P Y D T S S M Y S N A M A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 N1338 S K K E S A S N S R D S T H L
Sea Urchin Strong. purpuratus P10079 1064 112055 R973 D Y M T Y N E R A L G Y A A P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 33.6 78.1 N.A. 80.1 34 N.A. 33.4 34.4 33.4 35.9 N.A. 30.2 N.A. 22.9 23.4
Protein Similarity: 100 99.3 46.5 81.7 N.A. 85.7 45.9 N.A. 45.4 45.8 46 47.7 N.A. 40.6 N.A. 36 32
P-Site Identity: 100 100 26.6 13.3 N.A. 46.6 6.6 N.A. 26.6 6.6 6.6 20 N.A. 0 N.A. 6.6 0
P-Site Similarity: 100 100 40 20 N.A. 53.3 26.6 N.A. 33.3 33.3 13.3 26.6 N.A. 40 N.A. 33.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 24 0 16 8 16 39 8 16 8 8 0 31 16 16 % A
% Cys: 0 0 0 0 0 8 0 8 0 0 16 0 0 0 0 % C
% Asp: 8 0 0 8 8 0 0 0 8 0 8 0 0 0 0 % D
% Glu: 0 0 0 8 0 0 8 16 0 0 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % F
% Gly: 0 8 8 24 39 39 8 8 0 8 8 8 0 8 0 % G
% His: 0 0 0 0 8 0 0 0 0 24 0 0 0 8 0 % H
% Ile: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 16 8 0 0 0 8 0 0 8 0 0 8 0 0 % K
% Leu: 8 0 16 0 0 0 0 0 8 8 24 8 0 24 8 % L
% Met: 8 0 8 0 0 8 8 0 16 0 0 8 0 8 8 % M
% Asn: 0 0 0 16 0 8 0 8 8 8 0 8 8 0 0 % N
% Pro: 8 24 16 8 0 0 0 0 8 0 8 16 0 8 8 % P
% Gln: 16 0 0 0 0 0 8 0 0 8 0 0 0 0 0 % Q
% Arg: 8 0 24 0 8 8 0 8 0 8 0 24 0 0 8 % R
% Ser: 16 24 0 8 8 0 16 31 31 0 8 8 31 0 54 % S
% Thr: 8 0 8 8 16 16 8 0 8 0 8 16 16 0 0 % T
% Val: 0 0 8 0 0 0 0 0 0 16 0 0 8 16 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 0 8 8 8 8 0 0 16 0 8 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _