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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: S1PR3 All Species: 29.7
Human Site: S107 Identified Species: 65.33
UniProt: Q99500 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99500 NP_005217.2 378 42250 S107 G K K T F S L S P T V W F L R
Chimpanzee Pan troglodytes XP_520117 378 42218 S107 G K K T F S L S P T V W F L R
Rhesus Macaque Macaca mulatta XP_001107778 331 36908 A97 S D L L A G V A Y T A N L L L
Dog Lupus familis XP_541315 382 42671 S111 G K R T L S L S P T L W F L R
Cat Felis silvestris
Mouse Mus musculus Q9Z0U9 378 42252 S108 G R K T F S L S P T V W F L R
Rat Rattus norvegicus P48303 383 42727 T114 G A T T Y K L T P A Q W F L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520197 378 41947 T109 G A T T Y T L T P A Q W F L R
Chicken Gallus gallus XP_428818 380 42633 S112 G K K T L S L S S T I W F I R
Frog Xenopus laevis Q9PU17 366 41345 T119 G P N T R R L T V S T W L L R
Zebra Danio Brachydanio rerio Q9DDK4 362 40583 A108 G S M F V A L A A S V F S L L
Tiger Blowfish Takifugu rubipres Q9PUQ8 384 42694 S98 G E K T L Q L S P V L W F V R
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 45.5 86.6 N.A. 87.5 51.1 N.A. 52.3 76 34.9 51.8 61.4 N.A. N.A. N.A. N.A.
Protein Similarity: 100 100 60.8 90.8 N.A. 92.3 70.5 N.A. 70.3 83.9 57.9 69 73.9 N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 13.3 80 N.A. 93.3 53.3 N.A. 53.3 73.3 40 26.6 60 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 26.6 93.3 N.A. 100 66.6 N.A. 73.3 86.6 53.3 53.3 80 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 0 0 10 10 0 19 10 19 10 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 10 28 0 0 0 0 0 0 10 73 0 0 % F
% Gly: 91 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 10 0 0 10 0 % I
% Lys: 0 37 46 0 0 10 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 10 10 28 0 91 0 0 0 19 0 19 82 19 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 0 % N
% Pro: 0 10 0 0 0 0 0 0 64 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 10 0 0 0 0 19 0 0 0 0 % Q
% Arg: 0 10 10 0 10 10 0 0 0 0 0 0 0 0 82 % R
% Ser: 10 10 0 0 0 46 0 55 10 19 0 0 10 0 0 % S
% Thr: 0 0 19 82 0 10 0 28 0 55 10 0 0 0 0 % T
% Val: 0 0 0 0 10 0 10 0 10 10 37 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 82 0 0 0 % W
% Tyr: 0 0 0 0 19 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _