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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
S1PR3
All Species:
27.27
Human Site:
S224
Identified Species:
60
UniProt:
Q99500
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99500
NP_005217.2
378
42250
S224
R
I
Y
F
L
V
K
S
S
S
R
K
V
A
N
Chimpanzee
Pan troglodytes
XP_520117
378
42218
S224
R
I
Y
F
L
V
K
S
S
S
R
K
V
A
N
Rhesus Macaque
Macaca mulatta
XP_001107778
331
36908
F205
Y
H
K
H
Y
I
L
F
C
T
T
V
F
T
L
Dog
Lupus familis
XP_541315
382
42671
S228
R
I
Y
F
L
V
K
S
S
S
R
R
V
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0U9
378
42252
S225
R
I
Y
C
L
V
K
S
S
S
R
R
V
A
N
Rat
Rattus norvegicus
P48303
383
42727
T231
R
I
Y
S
L
V
R
T
R
S
R
R
L
T
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520197
378
41947
T226
L
I
Y
S
L
V
K
T
R
S
R
R
L
T
F
Chicken
Gallus gallus
XP_428818
380
42633
S229
R
I
Y
I
L
V
K
S
S
S
R
N
V
T
N
Frog
Xenopus laevis
Q9PU17
366
41345
Q236
H
I
F
V
Y
V
R
Q
K
T
M
R
M
S
R
Zebra Danio
Brachydanio rerio
Q9DDK4
362
40583
K218
S
R
K
L
V
F
R
K
V
A
N
G
R
G
S
Tiger Blowfish
Takifugu rubipres
Q9PUQ8
384
42694
S215
R
I
Y
I
L
V
K
S
S
S
Q
K
V
S
K
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
45.5
86.6
N.A.
87.5
51.1
N.A.
52.3
76
34.9
51.8
61.4
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
60.8
90.8
N.A.
92.3
70.5
N.A.
70.3
83.9
57.9
69
73.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
0
86.6
N.A.
86.6
46.6
N.A.
46.6
80
13.3
0
73.3
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
93.3
73.3
N.A.
66.6
80
53.3
26.6
86.6
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
10
0
0
0
37
0
% A
% Cys:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
10
28
0
10
0
10
0
0
0
0
10
0
19
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% G
% His:
10
10
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
82
0
19
0
10
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
19
0
0
0
64
10
10
0
0
28
0
0
10
% K
% Leu:
10
0
0
10
73
0
10
0
0
0
0
0
19
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
37
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% Q
% Arg:
64
10
0
0
0
0
28
0
19
0
64
46
10
0
10
% R
% Ser:
10
0
0
19
0
0
0
55
55
73
0
0
0
19
19
% S
% Thr:
0
0
0
0
0
0
0
19
0
19
10
0
0
37
0
% T
% Val:
0
0
0
10
10
82
0
0
10
0
0
10
55
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
73
0
19
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _