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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EYA3
All Species:
23.94
Human Site:
S373
Identified Species:
52.67
UniProt:
Q99504
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99504
NP_001981.2
573
62663
S373
V
H
V
E
D
V
A
S
D
D
N
G
Q
D
L
Chimpanzee
Pan troglodytes
XP_001151069
520
56787
F337
Y
S
F
S
T
D
G
F
S
G
S
G
G
S
G
Rhesus Macaque
Macaca mulatta
XP_001112789
573
62695
S373
V
H
V
E
D
V
A
S
D
D
N
G
Q
D
L
Dog
Lupus familis
XP_852446
449
49125
F266
Y
S
F
S
T
D
G
F
S
G
S
G
G
G
G
Cat
Felis silvestris
Mouse
Mus musculus
P97480
510
55927
F327
Y
S
F
S
T
D
G
F
S
G
S
G
G
S
G
Rat
Rattus norvegicus
NP_001101380
510
55858
F327
Y
S
F
S
T
D
G
F
S
G
S
G
G
S
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510467
531
57360
T348
L
S
N
Y
S
F
S
T
D
G
F
S
G
S
A
Chicken
Gallus gallus
XP_417715
574
63184
S374
V
H
I
E
D
V
A
S
D
D
N
G
Q
D
L
Frog
Xenopus laevis
NP_001089994
563
61878
S363
V
H
V
E
D
V
A
S
D
D
N
G
Q
D
L
Zebra Danio
Brachydanio rerio
NP_001073521
609
65733
S409
V
H
V
D
D
V
A
S
D
D
N
G
Q
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05201
766
80638
S563
V
H
I
D
D
V
S
S
D
D
N
G
Q
D
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.7
98.9
75.5
N.A.
84.4
84.8
N.A.
75.2
85
70.6
53
N.A.
34.9
N.A.
N.A.
N.A.
Protein Similarity:
100
90.7
99.4
76.9
N.A.
86.2
86.3
N.A.
82.9
91.6
82.7
68.6
N.A.
50.7
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
100
6.6
N.A.
6.6
6.6
N.A.
6.6
93.3
100
93.3
N.A.
80
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
100
13.3
N.A.
13.3
13.3
N.A.
26.6
100
100
100
N.A.
100
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
46
0
0
0
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
19
55
37
0
0
64
55
0
0
0
55
0
% D
% Glu:
0
0
0
37
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
37
0
0
10
0
37
0
0
10
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
37
0
0
46
0
91
46
10
37
% G
% His:
0
55
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
19
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
55
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
55
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
55
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
46
0
37
10
0
19
55
37
0
37
10
0
37
0
% S
% Thr:
0
0
0
0
37
0
0
10
0
0
0
0
0
0
0
% T
% Val:
55
0
37
0
0
55
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
37
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _