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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EYA3 All Species: 5.76
Human Site: Y163 Identified Species: 12.67
UniProt: Q99504 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99504 NP_001981.2 573 62663 Y163 P S P A H Y S Y P I Q A S S T
Chimpanzee Pan troglodytes XP_001151069 520 56787 P132 S S T I A N I P A A A V A S I
Rhesus Macaque Macaca mulatta XP_001112789 573 62695 Y163 P S P A H Y S Y P I Q A S S T
Dog Lupus familis XP_852446 449 49125 P61 S Q P Y A V Y P Q A T Q T Y G
Cat Felis silvestris
Mouse Mus musculus P97480 510 55927 I122 T S S A I A N I P A A A V A S
Rat Rattus norvegicus NP_001101380 510 55858 I122 T S S A I A N I P A A A V A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510467 531 57360 A143 S S T A T A A A N V S A V A S
Chicken Gallus gallus XP_417715 574 63184 S164 Q P S P A H Y S Y S I E A S T
Frog Xenopus laevis NP_001089994 563 61878 Q153 S S G V T S S Q S S P V L Y S
Zebra Danio Brachydanio rerio NP_001073521 609 65733 F199 Y P S Q G S C F T T S S V Y T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q05201 766 80638 N353 Y Y N E Q Y G N Y Y S P A N Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.7 98.9 75.5 N.A. 84.4 84.8 N.A. 75.2 85 70.6 53 N.A. 34.9 N.A. N.A. N.A.
Protein Similarity: 100 90.7 99.4 76.9 N.A. 86.2 86.3 N.A. 82.9 91.6 82.7 68.6 N.A. 50.7 N.A. N.A. N.A.
P-Site Identity: 100 13.3 100 6.6 N.A. 26.6 26.6 N.A. 20 13.3 13.3 6.6 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 20 100 13.3 N.A. 46.6 46.6 N.A. 46.6 26.6 20 20 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 46 28 28 10 10 10 37 28 46 28 28 0 % A
% Cys: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 10 0 0 0 0 0 0 0 10 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % F
% Gly: 0 0 10 0 10 0 10 0 0 0 0 0 0 0 10 % G
% His: 0 0 0 0 19 10 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 10 19 0 10 19 0 19 10 0 0 0 10 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 10 19 10 10 0 0 0 0 10 0 % N
% Pro: 19 19 28 10 0 0 0 19 37 0 10 10 0 0 0 % P
% Gln: 10 10 0 10 10 0 0 10 10 0 19 10 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 37 64 37 0 0 19 28 10 10 19 28 10 19 37 37 % S
% Thr: 19 0 19 0 19 0 0 0 10 10 10 0 10 0 37 % T
% Val: 0 0 0 10 0 10 0 0 0 10 0 19 37 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 19 10 0 10 0 28 19 19 19 10 0 0 0 28 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _