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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEU1
All Species:
12.12
Human Site:
S43
Identified Species:
38.1
UniProt:
Q99519
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99519
NP_000425.1
415
45467
S43
L
L
L
S
L
A
A
S
W
S
K
A
E
N
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113418
416
45709
S44
L
L
L
S
L
A
D
S
W
S
R
A
E
N
D
Dog
Lupus familis
XP_538838
415
44925
L43
L
L
W
P
L
A
G
L
G
A
G
I
K
N
D
Cat
Felis silvestris
Mouse
Mus musculus
O35657
409
44573
S37
L
L
V
S
A
A
E
S
E
A
R
A
E
D
D
Rat
Rattus norvegicus
Q99PW3
409
44677
S37
L
L
V
S
A
A
G
S
E
A
R
T
E
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086082
398
43964
F30
V
L
V
L
P
A
L
F
S
L
G
R
S
A
P
Zebra Danio
Brachydanio rerio
NP_001038374
383
42126
I26
A
R
A
D
K
T
Q
I
D
P
L
I
Y
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_790369
380
42263
S23
T
N
F
L
L
S
C
S
I
Q
V
N
P
I
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.1
87.9
N.A.
82.1
81.6
N.A.
N.A.
N.A.
57.5
55.9
N.A.
N.A.
N.A.
N.A.
45.7
Protein Similarity:
100
N.A.
98
92.5
N.A.
88.9
87.9
N.A.
N.A.
N.A.
73.2
71.5
N.A.
N.A.
N.A.
N.A.
62.4
P-Site Identity:
100
N.A.
86.6
40
N.A.
53.3
46.6
N.A.
N.A.
N.A.
13.3
0
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
N.A.
93.3
53.3
N.A.
80
73.3
N.A.
N.A.
N.A.
26.6
6.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
13
0
25
75
13
0
0
38
0
38
0
13
0
% A
% Cys:
0
0
0
0
0
0
13
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
13
0
0
13
0
13
0
0
0
0
25
63
% D
% Glu:
0
0
0
0
0
0
13
0
25
0
0
0
50
13
13
% E
% Phe:
0
0
13
0
0
0
0
13
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
25
0
13
0
25
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
13
13
0
0
25
0
13
13
% I
% Lys:
0
0
0
0
13
0
0
0
0
0
13
0
13
0
0
% K
% Leu:
63
75
25
25
50
0
13
13
0
13
13
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
13
0
0
0
0
0
0
0
0
0
13
0
38
0
% N
% Pro:
0
0
0
13
13
0
0
0
0
13
0
0
13
0
13
% P
% Gln:
0
0
0
0
0
0
13
0
0
13
0
0
0
0
0
% Q
% Arg:
0
13
0
0
0
0
0
0
0
0
38
13
0
0
0
% R
% Ser:
0
0
0
50
0
13
0
63
13
25
0
0
13
0
0
% S
% Thr:
13
0
0
0
0
13
0
0
0
0
0
13
0
0
0
% T
% Val:
13
0
38
0
0
0
0
0
0
0
13
0
0
0
0
% V
% Trp:
0
0
13
0
0
0
0
0
25
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _