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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MMP19 All Species: 8.48
Human Site: S33 Identified Species: 16.97
UniProt: Q99542 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99542 NP_002420.1 508 57357 S33 V A P V D Y L S Q Y G Y L Q K
Chimpanzee Pan troglodytes XP_001154045 470 52999 S17 F L L P M T V S G R V L G L A
Rhesus Macaque Macaca mulatta XP_001111624 508 57284 S33 E M A V E Y L S Q Y G Y L Q K
Dog Lupus familis XP_848410 547 61550 L34 E T A V D Y L L Q Y G Y L Q K
Cat Felis silvestris
Mouse Mus musculus Q9JHI0 527 59104 L34 E A V L D Y L L Q Y G Y L Q K
Rat Rattus norvegicus Q99PW6 618 70447 S60 A G Q N W L K S Y G Y L L P Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512754 558 61524 Q31 E A V D Y L I Q Y G Y L Q P P
Chicken Gallus gallus XP_415771 498 56504 F33 E R R R A E L F L Q K Y G Y L
Frog Xenopus laevis Q10835 469 53622 C15 L S L S F A Y C L S A P V P Q
Zebra Danio Brachydanio rerio XP_001337581 501 56922 E26 S P A Q G F L E Q Y G Y L Y K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393358 568 63683 S47 T A A M N Y L S Q F G Y L Q P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_001028820 562 62609 Q50 L S Y M S K Y Q G L P M S N D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.7 94.4 79.3 N.A. 76.6 32 N.A. 58.2 36.8 34.2 35.4 N.A. N.A. 34.3 N.A. 35
Protein Similarity: 100 91.3 97.2 84 N.A. 85.3 46.7 N.A. 68.6 50.5 46.2 51.9 N.A. N.A. 50.8 N.A. 49.8
P-Site Identity: 100 6.6 73.3 73.3 N.A. 73.3 13.3 N.A. 6.6 13.3 0 46.6 N.A. N.A. 60 N.A. 0
P-Site Similarity: 100 13.3 80 73.3 N.A. 80 13.3 N.A. 13.3 13.3 26.6 53.3 N.A. N.A. 80 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 34 34 0 9 9 0 0 0 0 9 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 25 0 0 0 0 0 0 0 0 0 9 % D
% Glu: 42 0 0 0 9 9 0 9 0 0 0 0 0 0 0 % E
% Phe: 9 0 0 0 9 9 0 9 0 9 0 0 0 0 0 % F
% Gly: 0 9 0 0 9 0 0 0 17 17 50 0 17 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 9 9 0 0 0 9 0 0 0 42 % K
% Leu: 17 9 17 9 0 17 59 17 17 9 0 25 59 9 9 % L
% Met: 0 9 0 17 9 0 0 0 0 0 0 9 0 0 0 % M
% Asn: 0 0 0 9 9 0 0 0 0 0 0 0 0 9 0 % N
% Pro: 0 9 9 9 0 0 0 0 0 0 9 9 0 25 17 % P
% Gln: 0 0 9 9 0 0 0 17 50 9 0 0 9 42 9 % Q
% Arg: 0 9 9 9 0 0 0 0 0 9 0 0 0 0 0 % R
% Ser: 9 17 0 9 9 0 0 42 0 9 0 0 9 0 0 % S
% Thr: 9 9 0 0 0 9 0 0 0 0 0 0 0 0 0 % T
% Val: 9 0 17 25 0 0 9 0 0 0 9 0 9 0 0 % V
% Trp: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 9 42 17 0 17 42 17 59 0 17 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _