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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP19
All Species:
16.36
Human Site:
S412
Identified Species:
32.73
UniProt:
Q99542
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99542
NP_002420.1
508
57357
S412
E
L
A
R
T
D
F
S
S
Y
P
K
P
I
K
Chimpanzee
Pan troglodytes
XP_001154045
470
52999
P375
K
K
L
N
R
V
E
P
N
L
D
A
A
L
Y
Rhesus Macaque
Macaca mulatta
XP_001111624
508
57284
S412
E
L
A
R
T
D
F
S
S
Y
P
K
P
I
K
Dog
Lupus familis
XP_848410
547
61550
S412
E
L
A
R
T
D
F
S
H
Y
P
K
P
I
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHI0
527
59104
S412
E
L
A
R
T
D
L
S
R
Y
P
K
P
I
K
Rat
Rattus norvegicus
Q99PW6
618
70447
P481
E
E
R
R
A
T
D
P
G
Y
P
K
P
I
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512754
558
61524
S411
E
L
A
W
N
D
F
S
R
Y
P
K
P
M
R
Chicken
Gallus gallus
XP_415771
498
56504
Q403
P
D
T
A
L
Y
F
Q
Q
L
R
R
L
V
L
Frog
Xenopus laevis
Q10835
469
53622
P374
K
L
H
E
L
G
F
P
K
T
L
K
A
I
D
Zebra Danio
Brachydanio rerio
XP_001337581
501
56922
F403
K
H
V
D
C
A
F
F
Y
Q
P
L
G
Q
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393358
568
63683
K433
P
S
Q
K
P
P
V
K
N
T
Y
P
K
L
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001028820
562
62609
E458
E
L
E
Q
R
V
D
E
G
Y
P
T
N
I
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.7
94.4
79.3
N.A.
76.6
32
N.A.
58.2
36.8
34.2
35.4
N.A.
N.A.
34.3
N.A.
35
Protein Similarity:
100
91.3
97.2
84
N.A.
85.3
46.7
N.A.
68.6
50.5
46.2
51.9
N.A.
N.A.
50.8
N.A.
49.8
P-Site Identity:
100
0
100
93.3
N.A.
86.6
46.6
N.A.
66.6
6.6
26.6
13.3
N.A.
N.A.
0
N.A.
40
P-Site Similarity:
100
20
100
93.3
N.A.
86.6
46.6
N.A.
80
20
33.3
20
N.A.
N.A.
20
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
42
9
9
9
0
0
0
0
0
9
17
0
0
% A
% Cys:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
9
0
42
17
0
0
0
9
0
0
0
9
% D
% Glu:
59
9
9
9
0
0
9
9
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
59
9
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
9
0
0
17
0
0
0
9
0
0
% G
% His:
0
9
9
0
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
59
9
% I
% Lys:
25
9
0
9
0
0
0
9
9
0
0
59
9
0
42
% K
% Leu:
0
59
9
0
17
0
9
0
0
17
9
9
9
17
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
0
0
9
9
0
0
0
17
0
0
0
9
0
0
% N
% Pro:
17
0
0
0
9
9
0
25
0
0
67
9
50
0
0
% P
% Gln:
0
0
9
9
0
0
0
9
9
9
0
0
0
9
0
% Q
% Arg:
0
0
9
42
17
0
0
0
17
0
9
9
0
0
9
% R
% Ser:
0
9
0
0
0
0
0
42
17
0
0
0
0
0
0
% S
% Thr:
0
0
9
0
34
9
0
0
0
17
0
9
0
0
9
% T
% Val:
0
0
9
0
0
17
9
0
0
0
0
0
0
9
0
% V
% Trp:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
0
0
9
59
9
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _