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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP19
All Species:
9.7
Human Site:
S489
Identified Species:
19.39
UniProt:
Q99542
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99542
NP_002420.1
508
57357
S489
S
G
G
N
T
T
P
S
G
T
G
I
T
L
D
Chimpanzee
Pan troglodytes
XP_001154045
470
52999
G452
G
G
N
T
T
P
S
G
T
G
I
T
L
D
T
Rhesus Macaque
Macaca mulatta
XP_001111624
508
57284
S489
S
G
G
D
T
T
P
S
G
M
G
T
T
L
D
Dog
Lupus familis
XP_848410
547
61550
S489
S
G
G
D
I
R
P
S
A
T
G
T
D
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHI0
527
59104
T489
T
G
D
V
T
P
S
T
T
D
T
V
L
G
T
Rat
Rattus norvegicus
Q99PW6
618
70447
D558
K
E
R
R
L
P
Q
D
D
V
D
I
M
V
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512754
558
61524
I488
D
D
L
L
P
T
G
I
A
L
P
N
G
T
D
Chicken
Gallus gallus
XP_415771
498
56504
A480
V
V
A
N
G
K
W
A
A
E
L
P
W
M
G
Frog
Xenopus laevis
Q10835
469
53622
S451
G
A
L
Q
F
E
Y
S
I
W
S
Q
R
I
T
Zebra Danio
Brachydanio rerio
XP_001337581
501
56922
R480
L
R
I
T
A
A
G
R
W
A
D
S
L
Q
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393358
568
63683
N510
T
L
G
N
G
S
M
N
R
W
Y
N
S
Q
C
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001028820
562
62609
T535
G
L
N
S
T
G
G
T
G
N
S
N
I
N
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.7
94.4
79.3
N.A.
76.6
32
N.A.
58.2
36.8
34.2
35.4
N.A.
N.A.
34.3
N.A.
35
Protein Similarity:
100
91.3
97.2
84
N.A.
85.3
46.7
N.A.
68.6
50.5
46.2
51.9
N.A.
N.A.
50.8
N.A.
49.8
P-Site Identity:
100
13.3
80
46.6
N.A.
13.3
6.6
N.A.
13.3
6.6
6.6
0
N.A.
N.A.
13.3
N.A.
13.3
P-Site Similarity:
100
13.3
86.6
53.3
N.A.
33.3
13.3
N.A.
13.3
20
13.3
0
N.A.
N.A.
40
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
9
0
9
9
0
9
25
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% C
% Asp:
9
9
9
17
0
0
0
9
9
9
17
0
9
9
25
% D
% Glu:
0
9
0
0
0
9
0
0
0
9
0
0
0
0
0
% E
% Phe:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
25
42
34
0
17
9
25
9
25
9
25
0
9
9
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
0
9
0
0
9
9
0
9
17
9
9
0
% I
% Lys:
9
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
17
17
9
9
0
0
0
0
9
9
0
25
17
0
% L
% Met:
0
0
0
0
0
0
9
0
0
9
0
0
9
9
0
% M
% Asn:
0
0
17
25
0
0
0
9
0
9
0
25
0
9
0
% N
% Pro:
0
0
0
0
9
25
25
0
0
0
9
9
0
9
0
% P
% Gln:
0
0
0
9
0
0
9
0
0
0
0
9
0
17
0
% Q
% Arg:
0
9
9
9
0
9
0
9
9
0
0
0
9
0
9
% R
% Ser:
25
0
0
9
0
9
17
34
0
0
17
9
9
0
9
% S
% Thr:
17
0
0
17
42
25
0
17
17
17
9
25
17
9
34
% T
% Val:
9
9
0
9
0
0
0
0
0
9
0
9
0
9
0
% V
% Trp:
0
0
0
0
0
0
9
0
9
17
0
0
9
0
9
% W
% Tyr:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _