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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP19
All Species:
10.91
Human Site:
T270
Identified Species:
21.82
UniProt:
Q99542
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99542
NP_002420.1
508
57357
T270
R
D
E
E
E
E
E
T
E
L
P
T
V
P
P
Chimpanzee
Pan troglodytes
XP_001154045
470
52999
Y237
M
A
P
V
Y
E
G
Y
R
P
H
F
K
L
H
Rhesus Macaque
Macaca mulatta
XP_001111624
508
57284
T270
K
D
E
E
E
E
E
T
E
L
P
T
V
S
P
Dog
Lupus familis
XP_848410
547
61550
M270
T
E
E
E
E
E
E
M
E
L
P
A
I
P
H
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHI0
527
59104
T270
T
R
D
E
E
E
E
T
E
M
L
T
V
S
P
Rat
Rattus norvegicus
Q99PW6
618
70447
P334
K
H
E
R
Q
P
R
P
P
R
P
P
L
G
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512754
558
61524
D269
E
E
E
I
Q
E
L
D
L
E
T
I
E
P
P
Chicken
Gallus gallus
XP_415771
498
56504
S265
Q
N
L
Y
G
K
P
S
K
G
L
A
I
Q
L
Frog
Xenopus laevis
Q10835
469
53622
S236
D
H
S
R
D
P
G
S
L
M
F
P
V
Y
T
Zebra Danio
Brachydanio rerio
XP_001337581
501
56922
Q263
W
D
D
I
T
A
V
Q
Q
L
Y
G
K
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393358
568
63683
G287
N
N
G
G
V
P
S
G
P
K
P
T
T
T
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001028820
562
62609
E312
P
G
P
N
P
K
P
E
P
G
P
N
P
G
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.7
94.4
79.3
N.A.
76.6
32
N.A.
58.2
36.8
34.2
35.4
N.A.
N.A.
34.3
N.A.
35
Protein Similarity:
100
91.3
97.2
84
N.A.
85.3
46.7
N.A.
68.6
50.5
46.2
51.9
N.A.
N.A.
50.8
N.A.
49.8
P-Site Identity:
100
6.6
86.6
60
N.A.
60
13.3
N.A.
26.6
0
6.6
26.6
N.A.
N.A.
13.3
N.A.
13.3
P-Site Similarity:
100
6.6
93.3
73.3
N.A.
73.3
33.3
N.A.
40
40
26.6
40
N.A.
N.A.
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
9
0
0
0
0
0
17
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
25
17
0
9
0
0
9
0
0
0
0
0
0
9
% D
% Glu:
9
17
42
34
34
50
34
9
34
9
0
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% F
% Gly:
0
9
9
9
9
0
17
9
0
17
0
9
0
17
0
% G
% His:
0
17
0
0
0
0
0
0
0
0
9
0
0
0
17
% H
% Ile:
0
0
0
17
0
0
0
0
0
0
0
9
17
0
0
% I
% Lys:
17
0
0
0
0
17
0
0
9
9
0
0
17
0
0
% K
% Leu:
0
0
9
0
0
0
9
0
17
34
17
0
9
9
9
% L
% Met:
9
0
0
0
0
0
0
9
0
17
0
0
0
0
0
% M
% Asn:
9
17
0
9
0
0
0
0
0
0
0
9
0
0
0
% N
% Pro:
9
0
17
0
9
25
17
9
25
9
50
17
9
34
50
% P
% Gln:
9
0
0
0
17
0
0
9
9
0
0
0
0
9
0
% Q
% Arg:
9
9
0
17
0
0
9
0
9
9
0
0
0
0
0
% R
% Ser:
0
0
9
0
0
0
9
17
0
0
0
0
0
17
0
% S
% Thr:
17
0
0
0
9
0
0
25
0
0
9
34
9
9
9
% T
% Val:
0
0
0
9
9
0
9
0
0
0
0
0
34
0
0
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
9
0
0
9
0
0
9
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _