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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP19
All Species:
19.39
Human Site:
Y305
Identified Species:
38.79
UniProt:
Q99542
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99542
NP_002420.1
508
57357
Y305
L
G
P
R
G
K
T
Y
A
F
K
G
D
Y
V
Chimpanzee
Pan troglodytes
XP_001154045
470
52999
L272
E
E
E
E
E
T
E
L
P
T
V
P
P
E
P
Rhesus Macaque
Macaca mulatta
XP_001111624
508
57284
Y305
L
G
P
R
G
T
T
Y
A
F
K
G
D
Y
V
Dog
Lupus familis
XP_848410
547
61550
Y305
L
G
P
R
G
K
T
Y
A
F
K
G
N
Y
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHI0
527
59104
Y305
L
G
P
R
G
K
T
Y
A
F
K
G
D
Y
V
Rat
Rattus norvegicus
Q99PW6
618
70447
V369
L
F
R
G
E
M
F
V
F
K
D
R
W
F
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512754
558
61524
Y304
F
G
P
H
L
K
T
Y
A
F
K
G
D
Y
V
Chicken
Gallus gallus
XP_415771
498
56504
Y300
Q
R
R
S
L
S
T
Y
Y
C
H
S
F
F
D
Frog
Xenopus laevis
Q10835
469
53622
P271
Y
G
P
G
N
R
D
P
H
P
K
H
P
K
T
Zebra Danio
Brachydanio rerio
XP_001337581
501
56922
S298
I
S
Q
D
P
R
E
S
S
L
T
P
N
Y
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393358
568
63683
V322
S
A
E
G
H
M
Y
V
F
K
G
D
R
Y
W
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001028820
562
62609
S347
G
E
L
F
A
F
Q
S
D
I
Y
W
R
L
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.7
94.4
79.3
N.A.
76.6
32
N.A.
58.2
36.8
34.2
35.4
N.A.
N.A.
34.3
N.A.
35
Protein Similarity:
100
91.3
97.2
84
N.A.
85.3
46.7
N.A.
68.6
50.5
46.2
51.9
N.A.
N.A.
50.8
N.A.
49.8
P-Site Identity:
100
0
93.3
93.3
N.A.
100
6.6
N.A.
80
13.3
20
6.6
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
100
0
93.3
100
N.A.
100
13.3
N.A.
80
20
26.6
33.3
N.A.
N.A.
6.6
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
9
0
0
0
42
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
9
% C
% Asp:
0
0
0
9
0
0
9
0
9
0
9
9
34
0
9
% D
% Glu:
9
17
17
9
17
0
17
0
0
0
0
0
0
9
0
% E
% Phe:
9
9
0
9
0
9
9
0
17
42
0
0
9
17
0
% F
% Gly:
9
50
0
25
34
0
0
0
0
0
9
42
0
0
0
% G
% His:
0
0
0
9
9
0
0
0
9
0
9
9
0
0
0
% H
% Ile:
9
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
34
0
0
0
17
50
0
0
9
0
% K
% Leu:
42
0
9
0
17
0
0
9
0
9
0
0
0
9
0
% L
% Met:
0
0
0
0
0
17
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
0
0
0
0
0
0
0
17
0
0
% N
% Pro:
0
0
50
0
9
0
0
9
9
9
0
17
17
0
9
% P
% Gln:
9
0
9
0
0
0
9
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
17
34
0
17
0
0
0
0
0
9
17
0
9
% R
% Ser:
9
9
0
9
0
9
0
17
9
0
0
9
0
0
0
% S
% Thr:
0
0
0
0
0
17
50
0
0
9
9
0
0
0
9
% T
% Val:
0
0
0
0
0
0
0
17
0
0
9
0
0
0
42
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
9
9
0
17
% W
% Tyr:
9
0
0
0
0
0
9
50
9
0
9
0
0
59
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _