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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP19
All Species:
15.15
Human Site:
Y35
Identified Species:
30.3
UniProt:
Q99542
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99542
NP_002420.1
508
57357
Y35
P
V
D
Y
L
S
Q
Y
G
Y
L
Q
K
P
L
Chimpanzee
Pan troglodytes
XP_001154045
470
52999
R19
L
P
M
T
V
S
G
R
V
L
G
L
A
E
V
Rhesus Macaque
Macaca mulatta
XP_001111624
508
57284
Y35
A
V
E
Y
L
S
Q
Y
G
Y
L
Q
K
P
L
Dog
Lupus familis
XP_848410
547
61550
Y36
A
V
D
Y
L
L
Q
Y
G
Y
L
Q
K
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHI0
527
59104
Y36
V
L
D
Y
L
L
Q
Y
G
Y
L
Q
K
P
L
Rat
Rattus norvegicus
Q99PW6
618
70447
G62
Q
N
W
L
K
S
Y
G
Y
L
L
P
Y
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512754
558
61524
G33
V
D
Y
L
I
Q
Y
G
Y
L
Q
P
P
L
E
Chicken
Gallus gallus
XP_415771
498
56504
Q35
R
R
A
E
L
F
L
Q
K
Y
G
Y
L
G
A
Frog
Xenopus laevis
Q10835
469
53622
S17
L
S
F
A
Y
C
L
S
A
P
V
P
Q
D
E
Zebra Danio
Brachydanio rerio
XP_001337581
501
56922
Y28
A
Q
G
F
L
E
Q
Y
G
Y
L
Y
K
D
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393358
568
63683
F49
A
M
N
Y
L
S
Q
F
G
Y
L
Q
P
M
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001028820
562
62609
L52
Y
M
S
K
Y
Q
G
L
P
M
S
N
D
P
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.7
94.4
79.3
N.A.
76.6
32
N.A.
58.2
36.8
34.2
35.4
N.A.
N.A.
34.3
N.A.
35
Protein Similarity:
100
91.3
97.2
84
N.A.
85.3
46.7
N.A.
68.6
50.5
46.2
51.9
N.A.
N.A.
50.8
N.A.
49.8
P-Site Identity:
100
6.6
86.6
86.6
N.A.
80
13.3
N.A.
0
13.3
0
46.6
N.A.
N.A.
53.3
N.A.
6.6
P-Site Similarity:
100
20
93.3
86.6
N.A.
86.6
13.3
N.A.
6.6
13.3
13.3
53.3
N.A.
N.A.
73.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
0
9
9
0
0
0
0
9
0
0
0
9
0
9
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
25
0
0
0
0
0
0
0
0
0
9
17
0
% D
% Glu:
0
0
9
9
0
9
0
0
0
0
0
0
0
17
17
% E
% Phe:
0
0
9
9
0
9
0
9
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
0
0
17
17
50
0
17
0
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
9
9
0
0
0
9
0
0
0
42
0
0
% K
% Leu:
17
9
0
17
59
17
17
9
0
25
59
9
9
9
34
% L
% Met:
0
17
9
0
0
0
0
0
0
9
0
0
0
9
0
% M
% Asn:
0
9
9
0
0
0
0
0
0
0
0
9
0
0
25
% N
% Pro:
9
9
0
0
0
0
0
0
9
9
0
25
17
42
0
% P
% Gln:
9
9
0
0
0
17
50
9
0
0
9
42
9
0
0
% Q
% Arg:
9
9
0
0
0
0
0
9
0
0
0
0
0
0
0
% R
% Ser:
0
9
9
0
0
42
0
9
0
0
9
0
0
0
9
% S
% Thr:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
17
25
0
0
9
0
0
0
9
0
9
0
0
0
9
% V
% Trp:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
9
42
17
0
17
42
17
59
0
17
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _