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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP19
All Species:
20.3
Human Site:
Y385
Identified Species:
40.61
UniProt:
Q99542
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99542
NP_002420.1
508
57357
Y385
P
N
L
D
A
A
L
Y
W
P
L
N
Q
K
V
Chimpanzee
Pan troglodytes
XP_001154045
470
52999
F348
P
R
T
Q
W
I
H
F
F
K
G
D
K
V
W
Rhesus Macaque
Macaca mulatta
XP_001111624
508
57284
Y385
P
N
L
D
A
A
F
Y
W
P
L
N
Q
K
V
Dog
Lupus familis
XP_848410
547
61550
Y385
P
N
L
D
A
A
L
Y
W
P
F
N
Q
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHI0
527
59104
Y385
P
N
L
D
A
A
L
Y
W
P
V
N
Q
K
V
Rat
Rattus norvegicus
Q99PW6
618
70447
R454
E
G
I
D
T
A
L
R
W
E
P
V
G
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512754
558
61524
Y384
P
N
L
D
A
A
L
Y
W
P
L
N
Q
K
I
Chicken
Gallus gallus
XP_415771
498
56504
H376
G
R
C
W
N
Y
H
H
S
T
L
M
S
G
F
Frog
Xenopus laevis
Q10835
469
53622
F347
A
K
D
L
S
Y
L
F
R
G
K
K
F
W
A
Zebra Danio
Brachydanio rerio
XP_001337581
501
56922
Y376
K
G
R
R
M
W
R
Y
S
G
S
N
L
D
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393358
568
63683
V406
D
N
I
D
T
V
T
V
W
T
G
N
G
K
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001028820
562
62609
S431
A
N
L
D
A
V
I
S
F
S
E
F
S
K
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.7
94.4
79.3
N.A.
76.6
32
N.A.
58.2
36.8
34.2
35.4
N.A.
N.A.
34.3
N.A.
35
Protein Similarity:
100
91.3
97.2
84
N.A.
85.3
46.7
N.A.
68.6
50.5
46.2
51.9
N.A.
N.A.
50.8
N.A.
49.8
P-Site Identity:
100
6.6
93.3
93.3
N.A.
93.3
33.3
N.A.
93.3
6.6
6.6
13.3
N.A.
N.A.
33.3
N.A.
33.3
P-Site Similarity:
100
33.3
93.3
93.3
N.A.
100
40
N.A.
100
13.3
20
13.3
N.A.
N.A.
46.6
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
0
0
50
50
0
0
0
0
0
0
0
0
9
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
9
67
0
0
0
0
0
0
0
9
0
9
0
% D
% Glu:
9
0
0
0
0
0
0
0
0
9
9
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
9
17
17
0
9
9
9
0
9
% F
% Gly:
9
17
0
0
0
0
0
0
0
17
17
0
17
9
0
% G
% His:
0
0
0
0
0
0
17
9
0
0
0
0
0
0
0
% H
% Ile:
0
0
17
0
0
9
9
0
0
0
0
0
0
0
9
% I
% Lys:
9
9
0
0
0
0
0
0
0
9
9
9
9
67
0
% K
% Leu:
0
0
50
9
0
0
50
0
0
0
34
0
9
0
9
% L
% Met:
0
0
0
0
9
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
0
59
0
0
9
0
0
0
0
0
0
59
0
0
0
% N
% Pro:
50
0
0
0
0
0
0
0
0
42
9
0
0
0
9
% P
% Gln:
0
0
0
9
0
0
0
0
0
0
0
0
42
0
0
% Q
% Arg:
0
17
9
9
0
0
9
9
9
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
9
0
0
9
17
9
9
0
17
0
0
% S
% Thr:
0
0
9
0
17
0
9
0
0
17
0
0
0
0
17
% T
% Val:
0
0
0
0
0
17
0
9
0
0
9
9
0
9
34
% V
% Trp:
0
0
0
9
9
9
0
0
59
0
0
0
0
9
9
% W
% Tyr:
0
0
0
0
0
17
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _