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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP19
All Species:
18.79
Human Site:
Y441
Identified Species:
37.58
UniProt:
Q99542
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99542
NP_002420.1
508
57357
Y441
S
W
Q
D
G
R
V
Y
F
F
K
G
K
V
Y
Chimpanzee
Pan troglodytes
XP_001154045
470
52999
S404
Y
W
H
A
R
V
Y
S
F
K
G
T
V
W
W
Rhesus Macaque
Macaca mulatta
XP_001111624
508
57284
F441
S
W
Q
D
G
R
V
F
F
F
K
G
K
V
Y
Dog
Lupus familis
XP_848410
547
61550
Y441
S
W
R
D
G
R
V
Y
F
F
K
D
K
Q
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHI0
527
59104
Y441
S
W
Q
D
G
Q
V
Y
F
F
K
G
K
E
Y
Rat
Rattus norvegicus
Q99PW6
618
70447
Y510
S
K
E
G
Y
Y
T
Y
F
Y
K
G
R
D
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512754
558
61524
Y440
S
W
K
N
G
G
I
Y
F
F
K
G
S
S
Y
Chicken
Gallus gallus
XP_415771
498
56504
R432
T
L
E
P
Y
Y
P
R
S
L
L
D
W
D
G
Frog
Xenopus laevis
Q10835
469
53622
F403
T
E
D
S
Y
W
S
F
D
E
E
A
R
T
L
Zebra Danio
Brachydanio rerio
XP_001337581
501
56922
Y432
S
L
S
M
E
L
Y
Y
P
R
P
L
R
D
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393358
568
63683
F462
V
Y
R
G
Y
T
Y
F
F
K
G
D
A
Y
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001028820
562
62609
Y487
V
H
I
D
G
T
A
Y
F
L
K
G
Y
E
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.7
94.4
79.3
N.A.
76.6
32
N.A.
58.2
36.8
34.2
35.4
N.A.
N.A.
34.3
N.A.
35
Protein Similarity:
100
91.3
97.2
84
N.A.
85.3
46.7
N.A.
68.6
50.5
46.2
51.9
N.A.
N.A.
50.8
N.A.
49.8
P-Site Identity:
100
13.3
93.3
80
N.A.
86.6
40
N.A.
60
0
0
13.3
N.A.
N.A.
13.3
N.A.
46.6
P-Site Similarity:
100
20
100
86.6
N.A.
93.3
60
N.A.
80
13.3
26.6
26.6
N.A.
N.A.
33.3
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
9
0
0
0
0
9
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
42
0
0
0
0
9
0
0
25
0
25
0
% D
% Glu:
0
9
17
0
9
0
0
0
0
9
9
0
0
17
0
% E
% Phe:
0
0
0
0
0
0
0
25
75
42
0
0
0
0
0
% F
% Gly:
0
0
0
17
50
9
0
0
0
0
17
50
0
0
9
% G
% His:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
0
0
0
9
0
0
0
0
0
0
0
0
% I
% Lys:
0
9
9
0
0
0
0
0
0
17
59
0
34
0
0
% K
% Leu:
0
17
0
0
0
9
0
0
0
17
9
9
0
0
9
% L
% Met:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
9
0
0
9
0
9
0
9
0
0
0
0
% P
% Gln:
0
0
25
0
0
9
0
0
0
0
0
0
0
9
0
% Q
% Arg:
0
0
17
0
9
25
0
9
0
9
0
0
25
0
0
% R
% Ser:
59
0
9
9
0
0
9
9
9
0
0
0
9
9
0
% S
% Thr:
17
0
0
0
0
17
9
0
0
0
0
9
0
9
0
% T
% Val:
17
0
0
0
0
9
34
0
0
0
0
0
9
17
0
% V
% Trp:
0
50
0
0
0
9
0
0
0
0
0
0
9
9
17
% W
% Tyr:
9
9
0
0
34
17
25
59
0
9
0
0
9
9
67
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _