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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
P2RX4
All Species:
24.24
Human Site:
Y367
Identified Species:
53.33
UniProt:
Q99571
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99571
NP_002551.2
388
43369
Y367
C
M
K
K
R
L
Y
Y
R
E
K
K
Y
K
Y
Chimpanzee
Pan troglodytes
XP_001164210
404
45295
Y383
C
M
K
K
R
L
Y
Y
R
E
K
K
Y
K
Y
Rhesus Macaque
Macaca mulatta
XP_001090844
340
37778
R320
M
K
K
R
L
Y
Y
R
E
K
K
Y
K
Y
V
Dog
Lupus familis
XP_543389
388
43458
Y367
C
M
K
K
R
Y
Y
Y
R
E
K
K
Y
K
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q9JJX6
388
43419
Y367
C
M
K
K
R
Y
Y
Y
R
D
K
K
Y
K
Y
Rat
Rattus norvegicus
P51577
388
43483
Y367
C
M
K
K
K
Y
Y
Y
R
D
K
K
Y
K
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519521
357
40415
V337
A
F
A
P
L
G
A
V
L
L
L
T
F
C
K
Chicken
Gallus gallus
NP_989622
385
43311
R364
V
L
Y
C
M
K
K
R
Y
F
Y
R
E
K
K
Frog
Xenopus laevis
NP_001082067
391
44317
Y368
F
F
K
K
R
H
Y
Y
R
E
K
K
Y
K
Y
Zebra Danio
Brachydanio rerio
NP_705939
389
43939
K367
V
L
T
F
M
K
R
K
Q
H
Y
K
E
Q
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792184
418
46849
Y395
L
L
K
K
R
F
L
Y
R
Q
K
K
F
Q
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96
77
89.9
N.A.
86.8
87.3
N.A.
46.9
75.7
69.3
58.8
N.A.
N.A.
N.A.
N.A.
46.6
Protein Similarity:
100
96
80.1
95.8
N.A.
94.5
94.3
N.A.
59.2
87.1
82.8
76.8
N.A.
N.A.
N.A.
N.A.
64.5
P-Site Identity:
100
100
20
93.3
N.A.
86.6
80
N.A.
0
6.6
80
6.6
N.A.
N.A.
N.A.
N.A.
46.6
P-Site Similarity:
100
100
33.3
93.3
N.A.
93.3
93.3
N.A.
6.6
20
80
26.6
N.A.
N.A.
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% A
% Cys:
46
0
0
10
0
0
0
0
0
0
0
0
0
10
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
10
37
0
0
19
0
0
% E
% Phe:
10
19
0
10
0
10
0
0
0
10
0
0
19
0
0
% F
% Gly:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
10
73
64
10
19
10
10
0
10
73
73
10
64
28
% K
% Leu:
10
28
0
0
19
19
10
0
10
10
10
0
0
0
10
% L
% Met:
10
46
0
0
19
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
10
10
0
0
0
19
0
% Q
% Arg:
0
0
0
10
55
0
10
19
64
0
0
10
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
10
0
0
0
0
0
0
0
0
10
0
0
0
% T
% Val:
19
0
0
0
0
0
0
10
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
37
64
64
10
0
19
10
55
10
55
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _