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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
P2RX4
All Species:
20.91
Human Site:
Y378
Identified Species:
46
UniProt:
Q99571
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99571
NP_002551.2
388
43369
Y378
K
Y
K
Y
V
E
D
Y
E
Q
G
L
A
S
E
Chimpanzee
Pan troglodytes
XP_001164210
404
45295
Y394
K
Y
K
Y
V
E
D
Y
E
Q
G
L
A
S
E
Rhesus Macaque
Macaca mulatta
XP_001090844
340
37778
E331
Y
K
Y
V
E
D
Y
E
Q
G
L
A
S
E
L
Dog
Lupus familis
XP_543389
388
43458
Y378
K
Y
K
Y
V
E
D
Y
E
Q
G
L
G
G
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9JJX6
388
43419
Y378
K
Y
K
Y
V
E
D
Y
E
Q
G
L
S
G
E
Rat
Rattus norvegicus
P51577
388
43483
Y378
K
Y
K
Y
V
E
D
Y
E
Q
G
L
S
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519521
357
40415
D348
T
F
C
K
C
S
R
D
N
C
K
Q
H
R
P
Chicken
Gallus gallus
NP_989622
385
43311
V375
R
E
K
K
Y
K
Y
V
E
D
Y
E
L
G
T
Frog
Xenopus laevis
NP_001082067
391
44317
Y379
K
Y
K
Y
V
E
D
Y
D
E
L
V
G
S
E
Zebra Danio
Brachydanio rerio
NP_705939
389
43939
V378
K
E
Q
K
Y
T
Y
V
D
D
F
G
L
L
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792184
418
46849
I406
K
F
Q
L
V
D
D
I
P
Y
E
D
A
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96
77
89.9
N.A.
86.8
87.3
N.A.
46.9
75.7
69.3
58.8
N.A.
N.A.
N.A.
N.A.
46.6
Protein Similarity:
100
96
80.1
95.8
N.A.
94.5
94.3
N.A.
59.2
87.1
82.8
76.8
N.A.
N.A.
N.A.
N.A.
64.5
P-Site Identity:
100
100
0
86.6
N.A.
86.6
86.6
N.A.
0
13.3
66.6
6.6
N.A.
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
100
100
20
86.6
N.A.
93.3
93.3
N.A.
6.6
26.6
86.6
20
N.A.
N.A.
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
10
28
0
0
% A
% Cys:
0
0
10
0
10
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
19
64
10
19
19
0
10
0
10
10
% D
% Glu:
0
19
0
0
10
55
0
10
55
10
10
10
0
10
55
% E
% Phe:
0
19
0
0
0
0
0
0
0
0
10
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
10
46
10
19
37
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
10
% H
% Ile:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% I
% Lys:
73
10
64
28
0
10
0
0
0
0
10
0
0
0
0
% K
% Leu:
0
0
0
10
0
0
0
0
0
0
19
46
19
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
10
% P
% Gln:
0
0
19
0
0
0
0
0
10
46
0
10
0
0
0
% Q
% Arg:
10
0
0
0
0
0
10
0
0
0
0
0
0
10
0
% R
% Ser:
0
0
0
0
0
10
0
0
0
0
0
0
28
28
0
% S
% Thr:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% T
% Val:
0
0
0
10
64
0
0
19
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
55
10
55
19
0
28
55
0
10
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _