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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
P2RX7
All Species:
17.27
Human Site:
S485
Identified Species:
42.22
UniProt:
Q99572
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99572
NP_002553.2
595
68559
S485
Q
C
G
S
C
L
P
S
Q
L
P
E
S
H
R
Chimpanzee
Pan troglodytes
XP_509436
595
68596
S485
Q
C
G
S
C
L
P
S
Q
L
P
E
S
H
R
Rhesus Macaque
Macaca mulatta
XP_001092531
595
68454
S485
Q
C
G
S
C
L
P
S
Q
L
P
K
S
H
R
Dog
Lupus familis
XP_543389
388
43458
R282
S
F
R
R
L
D
T
R
D
V
D
H
N
V
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1M0
595
68404
S485
Q
C
G
N
C
L
P
S
R
L
P
E
Q
R
R
Rat
Rattus norvegicus
Q64663
595
68373
S485
Q
C
G
N
C
L
P
S
Q
L
P
E
N
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516039
315
36270
K209
C
S
Q
S
Q
L
P
K
G
N
R
C
L
E
E
Chicken
Gallus gallus
XP_001235163
560
64402
Q454
W
C
C
C
G
R
C
Q
V
A
Q
K
H
H
E
Frog
Xenopus laevis
NP_001082196
553
62696
A447
R
S
A
M
L
P
P
A
W
C
K
C
N
K
C
Zebra Danio
Brachydanio rerio
NP_945335
596
67888
G478
S
P
T
W
C
Q
C
G
S
C
R
P
A
E
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.9
30.7
N.A.
80.5
80.1
N.A.
37.1
45.7
44.5
43.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.3
43.7
N.A.
87.7
89
N.A.
43
61.8
60.8
62.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
0
N.A.
73.3
80
N.A.
20
13.3
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
86.6
93.3
N.A.
20
20
26.6
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
10
0
10
0
0
10
0
0
% A
% Cys:
10
60
10
10
60
0
20
0
0
20
0
20
0
0
10
% C
% Asp:
0
0
0
0
0
10
0
0
10
0
10
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
40
0
20
20
% E
% Phe:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
50
0
10
0
0
10
10
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
10
40
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
10
0
0
10
20
0
10
0
% K
% Leu:
0
0
0
0
20
60
0
0
0
50
0
0
10
0
0
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
20
0
0
0
0
0
10
0
0
30
0
0
% N
% Pro:
0
10
0
0
0
10
70
0
0
0
50
10
0
0
0
% P
% Gln:
50
0
10
0
10
10
0
10
40
0
10
0
10
0
0
% Q
% Arg:
10
0
10
10
0
10
0
10
10
0
20
0
0
20
50
% R
% Ser:
20
20
0
40
0
0
0
50
10
0
0
0
30
0
10
% S
% Thr:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
10
% T
% Val:
0
0
0
0
0
0
0
0
10
10
0
0
0
10
0
% V
% Trp:
10
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _