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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: P2RX7 All Species: 13.33
Human Site: S540 Identified Species: 32.59
UniProt: Q99572 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99572 NP_002553.2 595 68559 S540 L L A L D V D S T N S R L R H
Chimpanzee Pan troglodytes XP_509436 595 68596 S540 L L A L D V D S T N S R L R H
Rhesus Macaque Macaca mulatta XP_001092531 595 68454 S540 L L A L D V D S T N S R L R H
Dog Lupus familis XP_543389 388 43458 P334 A G K F D I I P T M I N I G S
Cat Felis silvestris
Mouse Mus musculus Q9Z1M0 595 68404 A540 L L V L G E E A T N S R L R H
Rat Rattus norvegicus Q64663 595 68373 A540 L L A L E G E A I N S K L R H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516039 315 36270 L261 M T L D S D A L T R E L R H C
Chicken Gallus gallus XP_001235163 560 64402 S506 F L D L T G H S S N S Q L R R
Frog Xenopus laevis NP_001082196 553 62696 P499 Y A F Q Y D N P L S K T P I S
Zebra Danio Brachydanio rerio NP_945335 596 67888 S533 L A E L H E E S Q L R H G A Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96.9 30.7 N.A. 80.5 80.1 N.A. 37.1 45.7 44.5 43.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.6 98.3 43.7 N.A. 87.7 89 N.A. 43 61.8 60.8 62.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 13.3 N.A. 66.6 60 N.A. 6.6 46.6 0 20 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 26.6 N.A. 80 86.6 N.A. 13.3 60 13.3 33.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 20 40 0 0 0 10 20 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 0 0 10 10 40 20 30 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 10 0 10 20 30 0 0 0 10 0 0 0 0 % E
% Phe: 10 0 10 10 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 10 0 0 10 20 0 0 0 0 0 0 10 10 0 % G
% His: 0 0 0 0 10 0 10 0 0 0 0 10 0 10 50 % H
% Ile: 0 0 0 0 0 10 10 0 10 0 10 0 10 10 0 % I
% Lys: 0 0 10 0 0 0 0 0 0 0 10 10 0 0 0 % K
% Leu: 60 60 10 70 0 0 0 10 10 10 0 10 60 0 0 % L
% Met: 10 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 10 0 0 60 0 10 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 20 0 0 0 0 10 0 0 % P
% Gln: 0 0 0 10 0 0 0 0 10 0 0 10 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 10 10 40 10 60 10 % R
% Ser: 0 0 0 0 10 0 0 50 10 10 60 0 0 0 20 % S
% Thr: 0 10 0 0 10 0 0 0 60 0 0 10 0 0 0 % T
% Val: 0 0 10 0 0 30 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 10 0 0 0 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _