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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
P2RX7
All Species:
20.61
Human Site:
Y550
Identified Species:
50.37
UniProt:
Q99572
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99572
NP_002553.2
595
68559
Y550
S
R
L
R
H
C
A
Y
R
C
Y
A
T
W
R
Chimpanzee
Pan troglodytes
XP_509436
595
68596
Y550
S
R
L
R
H
C
A
Y
R
C
Y
A
T
W
R
Rhesus Macaque
Macaca mulatta
XP_001092531
595
68454
Y550
S
R
L
R
H
C
A
Y
R
C
Y
A
T
W
R
Dog
Lupus familis
XP_543389
388
43458
A344
I
N
I
G
S
G
L
A
L
L
G
V
A
T
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1M0
595
68404
Y550
S
R
L
R
H
R
A
Y
R
C
Y
A
T
W
R
Rat
Rattus norvegicus
Q64663
595
68373
Y550
S
K
L
R
H
C
A
Y
R
S
Y
A
T
W
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516039
315
36270
K271
E
L
R
H
C
A
Y
K
R
Y
I
D
W
R
F
Chicken
Gallus gallus
XP_001235163
560
64402
Y516
S
Q
L
R
R
I
A
Y
K
Q
Y
I
H
W
R
Frog
Xenopus laevis
NP_001082196
553
62696
H509
K
T
P
I
S
K
E
H
L
R
Y
Y
A
K
Q
Zebra Danio
Brachydanio rerio
NP_945335
596
67888
F543
R
H
G
A
Y
A
Q
F
I
R
W
R
F
G
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.9
30.7
N.A.
80.5
80.1
N.A.
37.1
45.7
44.5
43.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.3
43.7
N.A.
87.7
89
N.A.
43
61.8
60.8
62.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
93.3
86.6
N.A.
6.6
53.3
6.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
6.6
N.A.
93.3
93.3
N.A.
6.6
66.6
20
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
20
60
10
0
0
0
50
20
0
0
% A
% Cys:
0
0
0
0
10
40
0
0
0
40
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% D
% Glu:
10
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
10
0
0
0
0
10
0
10
% F
% Gly:
0
0
10
10
0
10
0
0
0
0
10
0
0
10
0
% G
% His:
0
10
0
10
50
0
0
10
0
0
0
0
10
0
0
% H
% Ile:
10
0
10
10
0
10
0
0
10
0
10
10
0
0
0
% I
% Lys:
10
10
0
0
0
10
0
10
10
0
0
0
0
10
0
% K
% Leu:
0
10
60
0
0
0
10
0
20
10
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
10
0
0
0
0
10
0
0
10
0
0
0
0
10
% Q
% Arg:
10
40
10
60
10
10
0
0
60
20
0
10
0
10
60
% R
% Ser:
60
0
0
0
20
0
0
0
0
10
0
0
0
0
0
% S
% Thr:
0
10
0
0
0
0
0
0
0
0
0
0
50
10
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
10
60
0
% W
% Tyr:
0
0
0
0
10
0
10
60
0
10
70
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _