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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3C
All Species:
23.33
Human Site:
S166
Identified Species:
39.49
UniProt:
Q99613
Number Species:
13
Phosphosite Substitution
Charge Score:
0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99613
NP_001032897.1
913
105344
S166
Y
K
Q
N
P
E
Q
S
A
D
E
D
A
E
K
Chimpanzee
Pan troglodytes
XP_510902
575
66735
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536923
913
105495
S166
Y
K
Q
N
P
E
Q
S
A
D
E
D
A
E
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1B4
911
105513
S166
Y
K
Q
N
P
E
Q
S
A
D
E
D
A
E
K
Rat
Rattus norvegicus
B5DFC8
911
105416
S166
Y
K
Q
N
P
E
Q
S
A
D
E
D
A
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4QR58
926
106985
S166
Y
K
Q
N
P
E
E
S
A
D
E
D
Q
E
K
Zebra Danio
Brachydanio rerio
Q6PFQ2
926
106349
S166
Y
K
E
N
P
E
Q
S
A
D
E
E
E
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZAX1
910
105636
E164
F
R
E
A
P
D
Q
E
S
E
A
E
D
E
V
Honey Bee
Apis mellifera
XP_623580
889
103950
D163
F
R
E
N
P
D
Q
D
D
D
E
E
E
E
K
Nematode Worm
Caenorhab. elegans
O02328
898
103824
V162
D
Q
Q
L
Q
D
L
V
T
D
Y
R
V
N
P
Sea Urchin
Strong. purpuratus
XP_787192
1170
135125
E164
Y
K
D
N
P
D
A
E
D
K
E
E
E
E
R
Poplar Tree
Populus trichocarpa
XP_002323353
895
101455
P174
I
N
K
Y
R
E
H
P
E
N
L
E
F
E
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49160
900
102930
E169
Y
R
E
A
P
E
V
E
E
E
K
Q
P
E
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SBD4
872
98381
T160
L
E
D
F
M
N
E
T
L
A
K
Q
K
V
T
Conservation
Percent
Protein Identity:
100
62.4
N.A.
98.5
N.A.
96.7
96.1
N.A.
N.A.
N.A.
79.2
76.1
N.A.
53
55.8
44.4
43.9
Protein Similarity:
100
62.6
N.A.
99.4
N.A.
97.6
97.6
N.A.
N.A.
N.A.
89.5
86.2
N.A.
70
72.5
64.5
58.9
P-Site Identity:
100
0
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
86.6
80
N.A.
20
46.6
13.3
40
P-Site Similarity:
100
0
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
93.3
N.A.
66.6
80
26.6
60
Percent
Protein Identity:
37
N.A.
N.A.
35.1
N.A.
33.6
Protein Similarity:
55.2
N.A.
N.A.
53
N.A.
54
P-Site Identity:
13.3
N.A.
N.A.
26.6
N.A.
0
P-Site Similarity:
40
N.A.
N.A.
53.3
N.A.
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
15
0
0
8
0
43
8
8
0
29
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
15
0
0
29
0
8
15
58
0
36
8
0
8
% D
% Glu:
0
8
29
0
0
58
15
22
15
15
58
36
22
79
8
% E
% Phe:
15
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
50
8
0
0
0
0
0
0
8
15
0
8
0
50
% K
% Leu:
8
0
0
8
0
0
8
0
8
0
8
0
0
0
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
58
0
8
0
0
0
8
0
0
0
8
0
% N
% Pro:
0
0
0
0
72
0
0
8
0
0
0
0
8
0
8
% P
% Gln:
0
8
43
0
8
0
50
0
0
0
0
15
8
0
0
% Q
% Arg:
0
22
0
0
8
0
0
0
0
0
0
8
0
0
8
% R
% Ser:
0
0
0
0
0
0
0
43
8
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
8
8
0
0
0
0
8
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
58
0
0
8
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _