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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3C
All Species:
18.79
Human Site:
S182
Identified Species:
31.79
UniProt:
Q99613
Number Species:
13
Phosphosite Substitution
Charge Score:
0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99613
NP_001032897.1
913
105344
S182
E
E
D
S
E
G
S
S
D
E
D
E
D
E
D
Chimpanzee
Pan troglodytes
XP_510902
575
66735
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536923
913
105495
S182
E
E
D
S
E
G
S
S
D
E
D
E
D
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1B4
911
105513
S182
E
E
D
S
E
G
S
S
D
E
D
E
D
E
D
Rat
Rattus norvegicus
B5DFC8
911
105416
S182
E
E
D
S
E
G
S
S
D
E
D
E
D
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4QR58
926
106985
S182
E
D
S
E
A
S
S
S
S
D
D
D
S
D
E
Zebra Danio
Brachydanio rerio
Q6PFQ2
926
106349
E182
D
I
G
S
G
S
S
E
S
D
D
D
D
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZAX1
910
105636
D180
A
L
E
S
D
G
G
D
A
G
D
D
S
D
A
Honey Bee
Apis mellifera
XP_623580
889
103950
A179
F
E
D
E
E
D
S
A
V
A
F
K
K
A
G
Nematode Worm
Caenorhab. elegans
O02328
898
103824
E178
E
D
G
Y
E
T
P
E
D
E
D
D
D
D
F
Sea Urchin
Strong. purpuratus
XP_787192
1170
135125
S180
V
E
K
K
D
E
E
S
D
S
E
E
D
E
P
Poplar Tree
Populus trichocarpa
XP_002323353
895
101455
N190
P
S
K
I
A
M
S
N
E
E
D
E
D
N
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49160
900
102930
D185
D
D
D
D
D
D
D
D
E
V
E
D
D
D
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SBD4
872
98381
A176
K
K
M
N
A
T
N
A
R
G
L
N
A
V
K
Conservation
Percent
Protein Identity:
100
62.4
N.A.
98.5
N.A.
96.7
96.1
N.A.
N.A.
N.A.
79.2
76.1
N.A.
53
55.8
44.4
43.9
Protein Similarity:
100
62.6
N.A.
99.4
N.A.
97.6
97.6
N.A.
N.A.
N.A.
89.5
86.2
N.A.
70
72.5
64.5
58.9
P-Site Identity:
100
0
N.A.
100
N.A.
100
93.3
N.A.
N.A.
N.A.
26.6
33.3
N.A.
20
26.6
40
40
P-Site Similarity:
100
0
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
60
60
N.A.
46.6
40
60
53.3
Percent
Protein Identity:
37
N.A.
N.A.
35.1
N.A.
33.6
Protein Similarity:
55.2
N.A.
N.A.
53
N.A.
54
P-Site Identity:
33.3
N.A.
N.A.
20
N.A.
0
P-Site Similarity:
46.6
N.A.
N.A.
66.6
N.A.
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
22
0
0
15
8
8
0
0
8
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
22
43
8
22
15
8
15
43
15
65
36
65
43
43
% D
% Glu:
43
43
8
15
43
8
8
15
15
43
15
43
0
29
8
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% F
% Gly:
0
0
15
0
8
36
8
0
0
15
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
8
15
8
0
0
0
0
0
0
0
8
8
0
8
% K
% Leu:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% L
% Met:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
8
8
0
0
0
8
0
8
0
% N
% Pro:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
8
8
43
0
15
58
43
15
8
0
0
15
0
0
% S
% Thr:
0
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
0
0
0
8
8
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _