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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF3C All Species: 6.36
Human Site: S205 Identified Species: 10.77
UniProt: Q99613 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99613 NP_001032897.1 913 105344 S205 K K K S E A P S G E S R K F L
Chimpanzee Pan troglodytes XP_510902 575 66735
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536923 913 105495 S205 K K K S E A P S G E S R K F L
Cat Felis silvestris
Mouse Mus musculus Q8R1B4 911 105513 G205 K K K Q E S S G E S R K F H K
Rat Rattus norvegicus B5DFC8 911 105416 G205 K K K P D S S G E S R K F H K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q4QR58 926 106985 P205 K K A E S A P P E S R S K F L
Zebra Danio Brachydanio rerio Q6PFQ2 926 106349 E205 K K K P Q E E E K K A P E A S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster A1ZAX1 910 105636 P203 P K A V K S A P A K A A P A D
Honey Bee Apis mellifera XP_623580 889 103950 A202 S K F K K N V A D G E E G S E
Nematode Worm Caenorhab. elegans O02328 898 103824 S201 E K S P G K P S E K A A V S D
Sea Urchin Strong. purpuratus XP_787192 1170 135125 Q203 V A P P K V K Q E G D Y D D E
Poplar Tree Populus trichocarpa XP_002323353 895 101455 K213 G W E K M M S K K D K L M D K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O49160 900 102930 E208 D P G S D V D E P T D N L T W
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SBD4 872 98381 A199 E Y Q T Q I D A Y R K D A D A
Conservation
Percent
Protein Identity: 100 62.4 N.A. 98.5 N.A. 96.7 96.1 N.A. N.A. N.A. 79.2 76.1 N.A. 53 55.8 44.4 43.9
Protein Similarity: 100 62.6 N.A. 99.4 N.A. 97.6 97.6 N.A. N.A. N.A. 89.5 86.2 N.A. 70 72.5 64.5 58.9
P-Site Identity: 100 0 N.A. 100 N.A. 26.6 20 N.A. N.A. N.A. 46.6 20 N.A. 6.6 6.6 20 0
P-Site Similarity: 100 0 N.A. 100 N.A. 40 40 N.A. N.A. N.A. 46.6 46.6 N.A. 33.3 20 40 6.6
Percent
Protein Identity: 37 N.A. N.A. 35.1 N.A. 33.6
Protein Similarity: 55.2 N.A. N.A. 53 N.A. 54
P-Site Identity: 0 N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 13.3 N.A. N.A. 13.3 N.A. 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 15 0 0 22 8 15 8 0 22 15 8 15 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 15 0 15 0 8 8 15 8 8 22 15 % D
% Glu: 15 0 8 8 22 8 8 15 36 15 8 8 8 0 15 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 0 15 22 0 % F
% Gly: 8 0 8 0 8 0 0 15 15 15 0 0 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 15 0 % H
% Ile: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % I
% Lys: 43 65 36 15 22 8 8 8 15 22 15 15 22 0 22 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 22 % L
% Met: 0 0 0 0 8 8 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % N
% Pro: 8 8 8 29 0 0 29 15 8 0 0 8 8 0 0 % P
% Gln: 0 0 8 8 15 0 0 8 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 22 15 0 0 0 % R
% Ser: 8 0 8 22 8 22 22 22 0 22 15 8 0 15 8 % S
% Thr: 0 0 0 8 0 0 0 0 0 8 0 0 0 8 0 % T
% Val: 8 0 0 8 0 15 8 0 0 0 0 0 8 0 0 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 8 0 0 0 0 0 0 8 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _