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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3C
All Species:
11.21
Human Site:
S225
Identified Species:
18.97
UniProt:
Q99613
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99613
NP_001032897.1
913
105344
S225
E
D
E
D
S
E
D
S
E
D
D
E
D
W
D
Chimpanzee
Pan troglodytes
XP_510902
575
66735
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536923
913
105495
S225
D
E
E
D
S
E
D
S
E
D
D
E
D
W
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1B4
911
105513
E225
D
E
D
S
E
D
S
E
D
E
E
W
D
T
S
Rat
Rattus norvegicus
B5DFC8
911
105416
E225
D
E
D
S
E
D
S
E
D
E
E
W
D
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4QR58
926
106985
E225
E
D
E
A
E
S
S
E
D
E
D
W
G
S
D
Zebra Danio
Brachydanio rerio
Q6PFQ2
926
106349
S225
A
A
D
E
E
S
E
S
D
D
D
E
D
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZAX1
910
105636
D223
D
S
I
D
W
D
S
D
S
E
S
E
T
E
S
Honey Bee
Apis mellifera
XP_623580
889
103950
S222
G
S
S
S
D
S
E
S
T
S
S
E
D
E
G
Nematode Worm
Caenorhab. elegans
O02328
898
103824
W221
D
D
D
D
S
S
N
W
S
S
E
P
E
S
N
Sea Urchin
Strong. purpuratus
XP_787192
1170
135125
S223
D
A
S
M
S
E
D
S
T
S
D
D
D
V
P
Poplar Tree
Populus trichocarpa
XP_002323353
895
101455
I233
P
S
E
I
T
W
D
I
V
N
K
K
F
K
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49160
900
102930
K228
K
K
D
K
L
L
E
K
L
M
N
K
D
P
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SBD4
872
98381
V219
D
E
V
A
A
P
K
V
V
S
K
V
R
F
E
Conservation
Percent
Protein Identity:
100
62.4
N.A.
98.5
N.A.
96.7
96.1
N.A.
N.A.
N.A.
79.2
76.1
N.A.
53
55.8
44.4
43.9
Protein Similarity:
100
62.6
N.A.
99.4
N.A.
97.6
97.6
N.A.
N.A.
N.A.
89.5
86.2
N.A.
70
72.5
64.5
58.9
P-Site Identity:
100
0
N.A.
86.6
N.A.
6.6
6.6
N.A.
N.A.
N.A.
33.3
33.3
N.A.
13.3
20
20
40
P-Site Similarity:
100
0
N.A.
100
N.A.
53.3
53.3
N.A.
N.A.
N.A.
46.6
66.6
N.A.
33.3
26.6
60
53.3
Percent
Protein Identity:
37
N.A.
N.A.
35.1
N.A.
33.6
Protein Similarity:
55.2
N.A.
N.A.
53
N.A.
54
P-Site Identity:
13.3
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
40
N.A.
N.A.
40
N.A.
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
15
0
15
8
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
50
22
36
29
8
22
29
8
29
22
36
8
58
0
22
% D
% Glu:
15
29
29
8
29
22
22
22
15
29
22
36
8
15
22
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
8
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
8
8
0
8
0
0
8
8
0
0
15
15
0
8
8
% K
% Leu:
0
0
0
0
8
8
0
0
8
0
0
0
0
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
8
8
0
0
0
8
% N
% Pro:
8
0
0
0
0
8
0
0
0
0
0
8
0
8
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
22
15
22
29
29
29
36
15
29
15
0
0
22
22
% S
% Thr:
0
0
0
0
8
0
0
0
15
0
0
0
8
15
0
% T
% Val:
0
0
8
0
0
0
0
8
15
0
0
8
0
8
0
% V
% Trp:
0
0
0
0
8
8
0
8
0
0
0
22
0
15
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _