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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3C
All Species:
16.36
Human Site:
S286
Identified Species:
27.69
UniProt:
Q99613
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99613
NP_001032897.1
913
105344
S286
K
K
K
H
D
R
K
S
K
R
L
D
E
E
E
Chimpanzee
Pan troglodytes
XP_510902
575
66735
E58
L
A
T
Y
M
K
P
E
M
W
G
K
C
L
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536923
913
105495
S286
K
K
K
H
D
R
K
S
K
R
L
D
E
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1B4
911
105513
S284
K
K
K
H
D
R
K
S
K
R
L
D
E
E
E
Rat
Rattus norvegicus
B5DFC8
911
105416
S284
K
K
K
H
D
R
K
S
K
R
M
D
E
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4QR58
926
106985
K284
K
K
Q
H
R
K
V
K
R
K
D
E
E
G
E
Zebra Danio
Brachydanio rerio
Q6PFQ2
926
106349
K283
R
R
R
R
H
K
K
K
E
R
I
E
E
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZAX1
910
105636
W282
E
D
D
E
D
G
E
W
E
T
V
V
K
G
H
Honey Bee
Apis mellifera
XP_623580
889
103950
E276
K
K
D
E
D
D
E
E
G
E
W
E
T
V
K
Nematode Worm
Caenorhab. elegans
O02328
898
103824
W281
E
E
D
D
D
A
D
W
T
P
V
N
R
E
K
Sea Urchin
Strong. purpuratus
XP_787192
1170
135125
E280
E
E
E
N
E
D
G
E
G
K
W
E
K
V
K
Poplar Tree
Populus trichocarpa
XP_002323353
895
101455
V286
V
V
S
A
Q
F
D
V
S
P
G
L
S
G
H
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49160
900
102930
L281
A
K
T
P
A
Q
K
L
E
I
L
F
S
V
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SBD4
872
98381
T275
E
S
R
G
K
K
N
T
D
R
L
E
Q
I
K
Conservation
Percent
Protein Identity:
100
62.4
N.A.
98.5
N.A.
96.7
96.1
N.A.
N.A.
N.A.
79.2
76.1
N.A.
53
55.8
44.4
43.9
Protein Similarity:
100
62.6
N.A.
99.4
N.A.
97.6
97.6
N.A.
N.A.
N.A.
89.5
86.2
N.A.
70
72.5
64.5
58.9
P-Site Identity:
100
0
N.A.
100
N.A.
100
93.3
N.A.
N.A.
N.A.
33.3
26.6
N.A.
6.6
20
13.3
0
P-Site Similarity:
100
20
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
66.6
73.3
N.A.
40
40
46.6
60
Percent
Protein Identity:
37
N.A.
N.A.
35.1
N.A.
33.6
Protein Similarity:
55.2
N.A.
N.A.
53
N.A.
54
P-Site Identity:
0
N.A.
N.A.
20
N.A.
13.3
P-Site Similarity:
0
N.A.
N.A.
33.3
N.A.
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
8
8
8
0
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
8
22
8
50
15
15
0
8
0
8
29
0
0
8
% D
% Glu:
29
15
8
15
8
0
15
22
22
8
0
36
43
43
36
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
8
0
8
8
0
15
0
15
0
0
22
0
% G
% His:
0
0
0
36
8
0
0
0
0
0
0
0
0
0
15
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
8
0
0
8
8
% I
% Lys:
43
50
29
0
8
29
43
15
29
15
0
8
15
0
29
% K
% Leu:
8
0
0
0
0
0
0
8
0
0
36
8
0
8
0
% L
% Met:
0
0
0
0
8
0
0
0
8
0
8
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
8
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
8
0
0
8
0
0
15
0
0
0
0
0
% P
% Gln:
0
0
8
0
8
8
0
0
0
0
0
0
8
0
0
% Q
% Arg:
8
8
15
8
8
29
0
0
8
43
0
0
8
0
0
% R
% Ser:
0
8
8
0
0
0
0
29
8
0
0
0
15
0
0
% S
% Thr:
0
0
15
0
0
0
0
8
8
8
0
0
8
0
0
% T
% Val:
8
8
0
0
0
0
8
8
0
0
15
8
0
22
0
% V
% Trp:
0
0
0
0
0
0
0
15
0
8
15
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _