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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3C
All Species:
27.58
Human Site:
T45
Identified Species:
46.67
UniProt:
Q99613
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99613
NP_001032897.1
913
105344
T45
L
S
E
D
E
E
D
T
K
R
V
V
R
S
A
Chimpanzee
Pan troglodytes
XP_510902
575
66735
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536923
913
105495
T45
L
S
E
D
E
E
D
T
K
R
V
V
R
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1B4
911
105513
T45
L
S
E
D
E
E
D
T
K
R
V
V
R
S
A
Rat
Rattus norvegicus
B5DFC8
911
105416
T45
L
S
E
D
E
E
D
T
K
R
V
V
R
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4QR58
926
106985
T45
L
S
D
D
E
E
D
T
K
R
V
V
R
S
A
Zebra Danio
Brachydanio rerio
Q6PFQ2
926
106349
T45
L
S
D
D
E
E
D
T
K
R
V
V
R
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZAX1
910
105636
K50
V
V
R
S
T
K
E
K
R
Y
E
N
L
T
S
Honey Bee
Apis mellifera
XP_623580
889
103950
S45
E
T
K
R
V
V
R
S
T
K
E
K
R
Y
E
Nematode Worm
Caenorhab. elegans
O02328
898
103824
E47
M
A
G
P
E
E
D
E
K
R
V
V
R
A
Q
Sea Urchin
Strong. purpuratus
XP_787192
1170
135125
R46
D
D
E
E
E
T
K
R
V
V
R
S
A
K
S
Poplar Tree
Populus trichocarpa
XP_002323353
895
101455
K56
D
S
D
D
S
D
D
K
K
R
V
V
R
S
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49160
900
102930
T48
E
D
D
D
D
T
D
T
K
R
V
V
K
P
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SBD4
872
98381
D45
S
S
S
E
E
E
S
D
E
E
E
S
D
E
E
Conservation
Percent
Protein Identity:
100
62.4
N.A.
98.5
N.A.
96.7
96.1
N.A.
N.A.
N.A.
79.2
76.1
N.A.
53
55.8
44.4
43.9
Protein Similarity:
100
62.6
N.A.
99.4
N.A.
97.6
97.6
N.A.
N.A.
N.A.
89.5
86.2
N.A.
70
72.5
64.5
58.9
P-Site Identity:
100
0
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
93.3
N.A.
0
6.6
53.3
13.3
P-Site Similarity:
100
0
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
100
100
N.A.
40
33.3
73.3
26.6
Percent
Protein Identity:
37
N.A.
N.A.
35.1
N.A.
33.6
Protein Similarity:
55.2
N.A.
N.A.
53
N.A.
54
P-Site Identity:
66.6
N.A.
N.A.
53.3
N.A.
20
P-Site Similarity:
80
N.A.
N.A.
73.3
N.A.
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
0
0
0
8
8
58
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
15
29
58
8
8
65
8
0
0
0
0
8
0
0
% D
% Glu:
15
0
36
15
65
58
8
8
8
8
22
0
0
8
15
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
8
0
0
8
8
15
65
8
0
8
8
8
0
% K
% Leu:
43
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
8
8
0
0
8
8
8
65
8
0
65
0
0
% R
% Ser:
8
58
8
8
8
0
8
8
0
0
0
15
0
50
15
% S
% Thr:
0
8
0
0
8
15
0
50
8
0
0
0
0
8
0
% T
% Val:
8
8
0
0
8
8
0
0
8
8
65
65
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _