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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3C
All Species:
43.64
Human Site:
T839
Identified Species:
73.85
UniProt:
Q99613
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99613
NP_001032897.1
913
105344
T839
M
A
S
L
D
Q
P
T
Q
T
V
V
M
H
R
Chimpanzee
Pan troglodytes
XP_510902
575
66735
Q502
A
S
L
D
Q
P
T
Q
T
V
V
M
H
R
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536923
913
105495
T839
M
A
S
L
D
Q
P
T
Q
T
V
V
M
H
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1B4
911
105513
T837
M
A
S
L
D
Q
P
T
Q
T
V
V
M
H
R
Rat
Rattus norvegicus
B5DFC8
911
105416
T837
M
A
S
L
D
Q
P
T
Q
T
V
V
M
H
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4QR58
926
106985
T841
M
A
S
L
D
Q
P
T
Q
T
V
V
M
H
G
Zebra Danio
Brachydanio rerio
Q6PFQ2
926
106349
T838
M
A
S
L
D
Q
P
T
Q
T
V
V
M
H
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZAX1
910
105636
S805
M
A
S
L
D
D
P
S
E
T
V
G
M
H
R
Honey Bee
Apis mellifera
XP_623580
889
103950
T804
M
A
S
L
D
D
P
T
E
T
V
V
M
H
R
Nematode Worm
Caenorhab. elegans
O02328
898
103824
T796
S
A
T
L
D
E
P
T
D
C
L
I
M
H
R
Sea Urchin
Strong. purpuratus
XP_787192
1170
135125
A1012
M
A
S
W
D
E
P
A
A
T
I
V
M
H
R
Poplar Tree
Populus trichocarpa
XP_002323353
895
101455
T759
H
A
S
W
D
Q
P
T
Q
C
I
V
F
Y
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49160
900
102930
T766
H
A
S
W
D
Q
P
T
R
C
I
V
F
H
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SBD4
872
98381
T777
A
A
A
L
D
Q
V
T
E
T
V
I
F
R
K
Conservation
Percent
Protein Identity:
100
62.4
N.A.
98.5
N.A.
96.7
96.1
N.A.
N.A.
N.A.
79.2
76.1
N.A.
53
55.8
44.4
43.9
Protein Similarity:
100
62.6
N.A.
99.4
N.A.
97.6
97.6
N.A.
N.A.
N.A.
89.5
86.2
N.A.
70
72.5
64.5
58.9
P-Site Identity:
100
6.6
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
100
N.A.
73.3
86.6
53.3
66.6
P-Site Similarity:
100
20
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
100
N.A.
86.6
93.3
80
80
Percent
Protein Identity:
37
N.A.
N.A.
35.1
N.A.
33.6
Protein Similarity:
55.2
N.A.
N.A.
53
N.A.
54
P-Site Identity:
53.3
N.A.
N.A.
53.3
N.A.
46.6
P-Site Similarity:
66.6
N.A.
N.A.
66.6
N.A.
73.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
93
8
0
0
0
0
8
8
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
22
0
0
0
0
0
% C
% Asp:
0
0
0
8
93
15
0
0
8
0
0
0
0
0
8
% D
% Glu:
0
0
0
0
0
15
0
0
22
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
22
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% G
% His:
15
0
0
0
0
0
0
0
0
0
0
0
8
79
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
22
15
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% K
% Leu:
0
0
8
72
0
0
0
0
0
0
8
0
0
0
0
% L
% Met:
65
0
0
0
0
0
0
0
0
0
0
8
72
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
8
86
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
65
0
8
50
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
0
0
0
0
15
65
% R
% Ser:
8
8
79
0
0
0
0
8
0
0
0
0
0
0
0
% S
% Thr:
0
0
8
0
0
0
8
79
8
72
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
8
0
0
8
72
72
0
0
0
% V
% Trp:
0
0
0
22
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _