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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TTC1 All Species: 9.09
Human Site: S148 Identified Species: 14.29
UniProt: Q99614 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99614 NP_003305.1 292 33526 S148 R A L E M C P S C F Q K E R S
Chimpanzee Pan troglodytes XP_001141156 292 33408 S148 R A L E M C P S C F Q K E R S
Rhesus Macaque Macaca mulatta XP_001083639 292 33646 C148 R A L E M C P C C F Q K E R S
Dog Lupus familis XP_546270 293 33698 S149 Q A L Q M C P S C F Q K D R S
Cat Felis silvestris
Mouse Mus musculus Q91Z38 292 33244 A148 Q A L Q M C P A C F Q K D R S
Rat Rattus norvegicus NP_001005529 292 33291 A148 Q A L Q M C P A C F Q K D R S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506286 295 33897 A150 R A L Q T C P A C Y R P D R S
Chicken Gallus gallus XP_414484 343 39127 A199 K A L Q I C P A C F Q K D R A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001007383 319 36919 V174 A A L K L C P V C F T K D R S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650543 263 29383 K145 N R A A A K I K L E A N K A A
Honey Bee Apis mellifera XP_623446 277 32061 L136 Q A I Q T C P L A Y S K E R S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782508 374 41657 L226 Q A L E A C P L C Y K K E R S
Poplar Tree Populus trichocarpa XP_002324511 278 30733 P137 V A L Q V S P P D V P S S I E
Maize Zea mays NP_001136906 255 27711 K139 V C F L K L G K H D E T V K E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_194777 277 30908 P139 L E L V Q E L P E S I E L R S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.5 87.7 N.A. 83.5 83.9 N.A. 72.5 59.1 N.A. 52.3 N.A. 42.8 44.5 N.A. 38.7
Protein Similarity: 100 99.6 98.6 93.1 N.A. 90.7 91.7 N.A. 84.4 72.5 N.A. 70.8 N.A. 60.9 64 N.A. 57.7
P-Site Identity: 100 100 93.3 80 N.A. 73.3 73.3 N.A. 53.3 60 N.A. 60 N.A. 0 46.6 N.A. 66.6
P-Site Similarity: 100 100 93.3 100 N.A. 100 100 N.A. 86.6 100 N.A. 80 N.A. 13.3 73.3 N.A. 86.6
Percent
Protein Identity: 35.2 32.5 N.A. 34.2 N.A. N.A.
Protein Similarity: 50.6 50.6 N.A. 55.1 N.A. N.A.
P-Site Identity: 20 0 N.A. 20 N.A. N.A.
P-Site Similarity: 33.3 13.3 N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 80 7 7 14 0 0 27 7 0 7 0 0 7 14 % A
% Cys: 0 7 0 0 0 74 0 7 67 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 7 7 0 0 40 0 0 % D
% Glu: 0 7 0 27 0 7 0 0 7 7 7 7 34 0 14 % E
% Phe: 0 0 7 0 0 0 0 0 0 54 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 7 0 7 0 7 0 0 0 7 0 0 7 0 % I
% Lys: 7 0 0 7 7 7 0 14 0 0 7 67 7 7 0 % K
% Leu: 7 0 80 7 7 7 7 14 7 0 0 0 7 0 0 % L
% Met: 0 0 0 0 40 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % N
% Pro: 0 0 0 0 0 0 80 14 0 0 7 7 0 0 0 % P
% Gln: 34 0 0 47 7 0 0 0 0 0 47 0 0 0 0 % Q
% Arg: 27 7 0 0 0 0 0 0 0 0 7 0 0 80 0 % R
% Ser: 0 0 0 0 0 7 0 20 0 7 7 7 7 0 74 % S
% Thr: 0 0 0 0 14 0 0 0 0 0 7 7 0 0 0 % T
% Val: 14 0 0 7 7 0 0 7 0 7 0 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 20 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _